SB 505124 | Tocris Bioscience 3263/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 505124

catalog :

3263/10

quantity :

10 mg (also 50 mg)

price :

335 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Adkar S, Wu C, Willard V, Dicks A, Ettyreddy A, Steward N, et al. Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing. Stem Cells. 2019;37:65-76 pubmed publisher
Asghar K, Brain J, Palmer J, Douglass S, Naemi F, O Boyle G, et al. Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis. Oncol Lett. 2017;14:5497-5504 pubmed publisher
Yang J, Ryan D, Wang W, Tsang J, Lan G, Masaki H, et al. Establishment of mouse expanded potential stem cells. Nature. 2017;550:393-397 pubmed publisher
Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, et al. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene. 2016;35:5388-5399 pubmed publisher
Van Boxtel A, Chesebro J, Heliot C, Ramel M, Stone R, Hill C. A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. Dev Cell. 2015;35:175-85 pubmed publisher
Biesemann N, Mendler L, Wietelmann A, Hermann S, Schäfers M, Kruger M, et al. Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circ Res. 2014;115:296-310 pubmed publisher
Ramel M, Hill C. The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Dev Biol. 2013;378:170-82 pubmed publisher

image

image 1 :

Cat.No. 3263 - SB 505124 C20H21N3O2 CAS No. 694433-59-5

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3263

SKU :

3263/10

product name :

SB 505124

description :

Selective inhibitor of TGF- RI, ALK4 and ALK7

target :

TGF-beta Receptor Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

335.4

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 505124 is a selective inhibitor of transforming growth factor- type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF- and activin; does not inhibit other ALK family members. Promotes adenine base editor activity in vivo and in vitro at 10 M.

product keywords :

SB505124 tgf tgfbeta tgfb tgfbrI tgfbetarI tgf rI receptors transforming growth factors alk5 alk4 alk7 inhibitors inhibits ABE adenine base editing editor TGF-beta Receptors BMP and Other Activin Receptors ALK 3263,

extended description :

Selective inhibitor of TGF- RI, ALK4 and ALK7

chemical name text :

2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine

formula :

C20H21N3O2

formula text :

C20H21N3O2

cas num :

694433-59-5

USD :

321

USD 2025 :

335 USD

product details :

Selective inhibitor of TGF- RI, ALK4 and ALK7

more info or order :

Tocris Bioscience product webpage