Gemcitabine hydrochloride | Tocris Bioscience 3259 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Gemcitabine hydrochloride

catalog :

3259

quantity :

10 mg (also 50 mg)

price :

121 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Marchetti C, Zyner K, Ohnmacht S, Robson M, Haider S, Morton J, et al. Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule. J Med Chem. 2018;61:2500-2517 pubmed publisher
Viotti M, Wilson C, MCCLELAND M, Koeppen H, Haley B, Jhunjhunwala S, et al. SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer. J Cell Biol. 2018;217:763-777 pubmed publisher
Li J, Wang R, Schweickert P, Karki A, Yang Y, Kong Y, et al. Plk1 inhibition enhances the efficacy of gemcitabine in human pancreatic cancer. Cell Cycle. 2016;15:711-9 pubmed publisher
Dolman M, van der Ploeg I, Koster J, Bate Eya L, Versteeg R, Caron H, et al. DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells. PLoS ONE. 2015;10:e0145744 pubmed publisher
Okita R, Wolf D, Yasuda K, Maeda A, Yukawa T, Saisho S, et al. Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells. PLoS ONE. 2015;10:e0139809 pubmed publisher
Di Veroli G, Fornari C, Goldlust I, Mills G, Koh S, Bramhall J, et al. An automated fitting procedure and software for dose-response curves with multiphasic features. Sci Rep. 2015;5:14701 pubmed publisher
Truman A, Kristjansdottir K, Wolfgeher D, Ricco N, Mayampurath A, Volchenboum S, et al. Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics. 2015;112:285-300 pubmed publisher
Mayor López L, Tristante E, Carballo Santana M, Carrasco Garcia E, Grasso S, Garcia Morales P, et al. Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity?. Transl Oncol. 2014;7:590-604 pubmed publisher
Jones R, Kotsantis P, Stewart G, Groth P, Petermann E. BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine. Mol Cancer Ther. 2014;13:2412-21 pubmed publisher
Bapiro T, Frese K, Courtin A, Bramhall J, Madhu B, Cook N, et al. Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo. Br J Cancer. 2014;111:318-25 pubmed publisher
Slee R, Grimes B, Bansal R, Gore J, Blackburn C, Brown L, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther. 2014;13:307-315 pubmed publisher
Clouser C, Bonnac L, Mansky L, Patterson S. Characterization of permeability, stability and anti-HIV-1 activity of decitabine and gemcitabine divalerate prodrugs. Antivir Chem Chemother. 2014;23:223-30 pubmed publisher
Chan G, Kleinheinz T, Peterson D, Moffat J. A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays. PLoS ONE. 2013;8:e63583 pubmed publisher
Song B, Liu X, Rice S, Kuang S, Elzey B, Konieczny S, et al. Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2013;12:58-68 pubmed publisher

product information

brand :

Tocris

master code :

3259

SKU :

3259/10

product name :

Gemcitabine hydrochloride

description :

DNA synthesis inhibitor

target :

DNA, RNA and Protein Synthesis Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

299.66

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo . Inhibits replication of MERS-CoV and SARS-CoV in vitro (EC50 values are 1,2 16 and 4.957 M, respectively).

catalog number base :

3259

product keywords :

DNA synthesis inhibitors inhibits Ribonucleotide reductases chemotherapeutics coronaviruses COVID-19 SARS-CoV MERS severe acute respiratory syndrome DNA, RNA and Protein Synthesis Ribonucleotide Reductase COVID-19 Coronavirus 3259,

extended description :

DNA synthesis inhibitor

chemical name text :

(+)-2 -Deoxy-2 ,2 -difluorocytidine hydrochloride

formula :

C 9 H 11 F 2 N 3 O 4 .HCl

formula text :

C9H11F2N3O4.HCl

cas num :

122111-03-9

2020 USD :

115

2021 USD :

121 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage