5-Fluorouracil | Tocris Bioscience 3257 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5-Fluorouracil

catalog :

3257

quantity :

50 mg

price :

63 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Fukushima K, Tsuchiya K, Kano Y, Horita N, Hibiya S, Hayashi R, et al. Atonal homolog 1 protein stabilized by tumor necrosis factor Î± induces high malignant potential in colon cancer cell line. Cancer Sci. 2015;106:1000-7 pubmed publisher
Robinson T, Liu J, Vizeacoumar F, Sun T, MacLean N, Egan S, et al. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS ONE. 2013;8:e78641 pubmed publisher

product information

brand :

Tocris

master code :

3257

SKU :

3257/50

product name :

5-Fluorouracil

description :

Thymidylate synthetase inhibitor

target :

Thymidylate Synthetase Inhibitor

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

130.08

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Anticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate synthase, causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively.

catalog number base :

3257

product keywords :

inhibitors inhibits RNA DNA synthesis thymidylate synthetases Synthases antimetabolites 5-FU chemotherapeutics 5-FU DNA, RNA and Protein Synthesis Thymidylate Synthetase 3257, Thymidylate synthetase inhibitor

extended description :

Thymidylate synthetase inhibitor

chemical name text :

5-Fluoro-2,4-(1H,3H)-pyrimidinedione

formula :

C 4 H 3 FN 2 O 2

formula text :

C4H3FN2O2

cas num :

51-21-8

2020 USD :

2021 USD :

63 USD

alt names :

5-FU

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage