PJ 34 hydrochloride | Tocris Bioscience 3255/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PJ 34 hydrochloride

catalog :

3255/10

quantity :

10 mg (also 50 mg)

price :

241 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kirby C, Cheung A, Fazal A, Shultz M, Stams T. Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:115-8 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3255

SKU :

3255/10

product name :

PJ 34 hydrochloride

description :

Potent PARP inhibitor

target :

Poly(ADP-ribose) Polymerase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at RT

observed molecular weight :

331.8

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo . Displays protective effects against cisplatin -induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC50 values are 3.7 and 16 M respectively).

product keywords :

Potent PARP inhibitors inhibits PolyADP-ribose Polymerases PJ34 hydrochloride Poly(ADP-ribose) Polymerase 3255,

extended description :

Potent PARP inhibitor

chemical name text :

N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride

formula :

C17H17N3O2.HCl

formula text :

C17H17N3O2.HCl

cas num :

344458-15-7

USD :

238

USD 2025 :

241 USD

product details :

Potent PARP inhibitor

more info or order :

Tocris Bioscience product webpage