Ro 61-8048 | Tocris Bioscience 3254/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ro 61-8048

catalog :

3254/10

quantity :

10 mg (also 50 mg)

price :

245 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Giménez Gómez P, Pérez Hernández M, Gutierrez Lopez M, Vidal R, Abuin Martínez C, O Shea E, et al. Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens. Neuropharmacology. 2018;135:581-591 pubmed publisher
Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M. Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands. Eur J Immunol. 2013;43:1727-34 pubmed publisher
Schmid M, Lehmann M, Lucius R, Gupta N. Apicomplexan parasite, Eimeria falciformis, co-opts host tryptophan catabolism for life cycle progression in mouse. J Biol Chem. 2012;287:20197-207 pubmed publisher
Mailankot M, Nagaraj R. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: apoptosis through the formation of 3-hydroxykynurenine. Int J Biochem Cell Biol. 2010;42:1446-54 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3254

SKU :

3254/10

product name :

Ro 61-8048

description :

Potent kynurenine 3-monooxygenase (KMO) inhibitor

target :

Hydroxylase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

421.45

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ro 61-8048 is a potent and competitive kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (Ki = 4.8 nM, IC50 = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities. Ro 61-8048 decreases nicotine self-administration in vivo . Ro 61-8048 prevents post-operative brain edema and consequent neuronal apoptosis in a rat model of surgically induced brain injury.

product keywords :

Potent kynurenine 3-hydroxylase inhibitors inhibits NMDA antagonists increases kynurenic acid levels Tryptophan Hydroxylase 11- 11-beta LTB-omega-Hydroxylase Kynurenine 3-Hydroxylase Hydroxylases Glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotr Hydroxylases NMDA Receptors Kynurenine 3-monooxygenase 3254,

extended description :

Potent kynurenine 3-monooxygenase (KMO) inhibitor

chemical name text :

3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide

formula :

C17H15N3O6S2

formula text :

C17H15N3O6S2

cas num :

199666-03-0

USD :

242

USD 2025 :

245 USD

product details :

Potent kynurenine 3-monooxygenase (KMO) inhibitor

more info or order :

Tocris Bioscience product webpage