Triptolide | Tocris Bioscience 3253/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Triptolide

catalog :

3253/1

quantity :

1 mg (also 10 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Petropoulos M, Karamichali A, Rossetti G, Freudenmann A, Iacovino L, Dionellis V, et al. Transcription-replication conflicts underlie sensitivity to PARP inhibitors. Nature. 2024;628:433-441 pubmed publisher
Tettey T, Gao X, Shao W, Li H, Story B, Chitsazan A, et al. A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing. Cell Rep. 2019;27:3770-3779.e7 pubmed publisher
Shao W, Alcantara S, Zeitlinger J. Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing. elife. 2019;8: pubmed publisher
Bowry A, Piberger A, Rojas P, Saponaro M, Petermann E. BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication. Cell Rep. 2018;25:2061-2069.e4 pubmed publisher
Dumelie J, Jaffrey S. Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq. elife. 2017;6: pubmed publisher
Liao R, Mizzen C. Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation. Epigenetics Chromatin. 2017;10:29 pubmed publisher
Zhao G, Yan G, Cheng J, Zhou X, Fang T, Sun H, et al. Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression. Sci Rep. 2015;5:7647 pubmed publisher
Filone C, Caballero I, Dower K, Mendillo M, Cowley G, Santagata S, et al. The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. PLoS Pathog. 2014;10:e1003904 pubmed publisher
Vollmer T, Stockhausen A, Zhang J. Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1). J Biol Chem. 2012;287:35212-21 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3253

SKU :

3253/1

product name :

Triptolide

description :

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

target :

NFkB/IkB Inhibitors

unit size :

1 mg (also 10 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

360.4

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Triptolide inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC50 = 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Triptolide blocks RNA synthesis in HeLa cells (IC50 = 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and induces apoptosis by blocking TNF- -mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity.

product keywords :

Blocks TNF- TNF-alpha-mediated c-IAP2 c-IAP1 induction inhibitors inhibits apoptosis TNF-alpha-induced NF- B NF-kappaB NF-kB activation X-Linked Apoptosis XIAP Nuclear Factor Kappa B Cytokine Signaling Signalling Transcription Factors Immunosuppressants DNA Polymerase RNA Polymerase DNA, RNA and Protein Synthesis Inhibitor of Apoptosis (IAP) 3253,

extended description :

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

chemical name text :

(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one

formula :

C20H24O6

formula text :

C20H24O6

cas num :

38748-32-2

USD :

162

USD 2025 :

169 USD

product details :

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

more info or order :

Tocris Bioscience product webpage