VU 0155041 | Tocris Bioscience 3248 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0155041

catalog :

3248

quantity :

10 mg (also 50 mg)

price :

59 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Jones C, Engers D, Thompson A, Field J, Blobaum A, Lindsley S, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate recepto. J Med Chem. 2011;54:7639-47 pubmed publisher
Duvoisin R, Villasana L, Davis M, Winder D, Raber J. Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav Brain Res. 2011;221:50-4 pubmed publisher
Williams R, Johnson K, Gentry P, Niswender C, Weaver C, Conn P, et al. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). Bioorg Med Chem Lett. 2009;19:4967-70 pubmed publisher

product information

brand :

Tocris

master code :

3248

SKU :

3248/10

product name :

VU 0155041

description :

Potent positive allosteric modulator of mGlu4 receptors

target :

Group III mGluR Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

316.18

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Active in in vivo models of Parkinson s disease following i.c.v. administration. Also available as sodium salt (Cat. No. 3311 ).

catalog number base :

3248

product keywords :

Potent positive allosteric mGlu4 mGluR4 agonists mGlur Group III Receptors Glutamate Metabotropic VU0155041 PAM Glutamate (Metabotropic) Group III Receptors 3248,

extended description :

Potent positive allosteric modulator of mGlu4 receptors

chemical name text :

cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid

formula :

C 14 H 15 Cl 2 NO 3

formula text :

C14H15Cl2NO3

cas num :

1093757-42-6

2020 USD :

2021 USD :

59 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage