LY 354740 | Tocris Bioscience 3246 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LY 354740

catalog :

3246

quantity :

10 mg (also 50 mg)

price :

208 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Dornier E, Rabas N, Mitchell L, Novo D, Dhayade S, Marco S, et al. Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nat Commun. 2017;8:2255 pubmed publisher
Chai H, Diaz Castro B, Shigetomi E, Monte E, Octeau J, Yu X, et al. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017;95:531-549.e9 pubmed publisher
Scholler P, Moreno Delgado D, Lecat Guillet N, Doumazane E, Monnier C, Charrier Savournin F, et al. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 2017;13:372-380 pubmed publisher
Yaeger D, Trussell L. Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci. 2015;35:4741-50 pubmed publisher
Copeland C, Neale S, Salt T. Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. Neuropharmacology. 2015;92:16-24 pubmed publisher

product information

brand :

Tocris

master code :

3246

SKU :

3246/10

product name :

LY 354740

description :

Potent and highly selective group II mGlu agonist

target :

Group II mGluR Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

185.18

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly selective and potent agonist of group II mGlu receptors (EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively and 100000 nM at mGlu4, mGlu7, mGlu1a and mGlu5a receptors). Displays antianxiety and antiaddictive activity in vivo . Orally and systemically active.

catalog number base :

3246

product keywords :

Potent selective group II mGlur agonists Group Receptors mGlu2 mGluR2 mGlu3 mGluR3 Glutamate Metabotropic LY354740 Glutamate (Metabotropic) Group II Receptors 3246,

extended description :

Potent and highly selective group II mGlu agonist

chemical name text :

(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

formula :

C 8 H 11 NO 4

formula text :

C8H11NO4

cas num :

176199-48-7

2020 USD :

203

2021 USD :

208 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage