product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
LY 354740
catalog :
3246/10
quantity :
10 mg (also 50 mg)
price :
269 USD
more info or order :
Tocris Bioscience product webpage
citations: 5
Reference
Dornier E, Rabas N, Mitchell L, Novo D, Dhayade S, Marco S, et al. Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nat Commun. 2017;8:2255 pubmed publisher
Chai H, Diaz Castro B, Shigetomi E, Monte E, Octeau J, Yu X, et al. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017;95:531-549.e9 pubmed publisher
Scholler P, Moreno Delgado D, Lecat Guillet N, Doumazane E, Monnier C, Charrier Savournin F, et al. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 2017;13:372-380 pubmed publisher
Yaeger D, Trussell L. Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci. 2015;35:4741-50 pubmed publisher
Copeland C, Neale S, Salt T. Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. Neuropharmacology. 2015;92:16-24 pubmed publisher
product information
brand :
Tocris
catalog number base :
3246
SKU :
3246/10
product name :
LY 354740
units size :
10 mg (also 50 mg)
description :
Potent and highly selective group II mGlu agonist
target :
Group II mGluR Agonists
category :
Small Molecules
purity :
98%
observed molecular weight :
185.18
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
LY 354740 is a highly selective and potent agonist of group II mGlu receptors (EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively and 100000 nM at mGlu4, mGlu7, mGlu1a and mGlu5a receptors). Displays antianxiety and antiaddictive activity in vivo . Orally and systemically active.
top caption :
Potent and highly selective group II mGlu agonist
extended description :
Potent and highly selective group II mGlu agonist
chemical name text :
(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
formula :
C8H11NO4
formula text :
C8H11NO4
cas num :
176199-48-7
USD :
269 USD
product details :
Potent and highly selective group II mGlu agonist
storage :
Store at +4°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK