product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
PF 573228
catalog :
3239/10
quantity :
10 mg (also 50 mg)
price :
291 USD
more info or order :
citations: 60
Reference
Nguemgo Kouam P, Buhler H, Hero T, Adamietz I. The increased adhesion of tumor cells to endothelial cells after irradiation can be reduced by FAK-inhibition. Radiat Oncol. 2019;14:25 pubmed publisher
Beerli C, Yakimovich A, Kilcher S, Reynoso G, Fläschner G, Muller D, et al. Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility. Nat Microbiol. 2019;4:216-225 pubmed publisher
Bastounis E, Yeh Y, Theriot J. Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin. Mol Biol Cell. 2018;29:1571-1589 pubmed publisher
Keasey M, Jia C, Pimentel L, Sante R, Lovins C, Hagg T. Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci. 2018;131: pubmed publisher
Ahrendsen J, HARLOW D, Finseth L, Bourne J, Hickey S, Gould E, et al. The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination. J Neurosci. 2018;38:787-802 pubmed publisher
Song H, Jun H, Kim J, Lee Y, Choi M, Kim J. Disruption of outer blood-retinal barrier by Toxoplasma gondii-infected monocytes is mediated by paracrinely activated FAK signaling. PLoS ONE. 2017;12:e0175159 pubmed publisher
Sero J, Bakal C. Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion. Cell Syst. 2017;4:84-96.e6 pubmed publisher
Wang Y, Gratzke C, Tamalunas A, Rutz B, Ciotkowska A, Strittmatter F, et al. Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2. Br J Pharmacol. 2016;173:3342-3358 pubmed publisher
Fu H, Tian Y, Zhou L, Zhou D, Tan R, Stolz D, et al. Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis. J Am Soc Nephrol. 2017;28:785-801 pubmed publisher
Hennigan K, Conroy P, Walsh M, Amin M, O Kennedy R, Ramasamy P, et al. Eosinophil peroxidase activates cells by HER2 receptor engagement and ?1-integrin clustering with downstream MAPK cell signaling. Clin Immunol. 2016;171:1-11 pubmed publisher
Alowayed N, Salker M, Zeng N, Singh Y, Lang F. LEFTY2 Controls Migration of Human Endometrial Cancer Cells via Focal Adhesion Kinase Activity (FAK) and miRNA-200a. Cell Physiol Biochem. 2016;39:815-26 pubmed publisher
Roa Espitia A, Hernández Rendón E, Baltiérrez Hoyos R, Muñoz Gotera R, Cote Vélez A, Jiménez I, et al. Focal adhesion kinase is required for actin polymerization and remodeling of the cytoskeleton during sperm capacitation. Biol Open. 2016;5:1189-99 pubmed publisher
Frolov A, Evans I, Li N, Sidlauskas K, Paliashvili K, Lockwood N, et al. Imatinib and Nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling. Sci Rep. 2016;6:27378 pubmed publisher
Rengarajan M, Hayer A, Theriot J. Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes. PLoS Pathog. 2016;12:e1005603 pubmed publisher
Du J, Zu Y, Li J, Du S, Xu Y, Zhang L, et al. Extracellular matrix stiffness dictates Wnt expression through integrin pathway. Sci Rep. 2016;6:20395 pubmed publisher
Zhang B, Luo Q, Chen Z, Shi Y, Ju Y, Yang L, et al. Increased nuclear stiffness via FAK-ERK1/2 signaling is necessary for synthetic mechano-growth factor E peptide-induced tenocyte migration. Sci Rep. 2016;6:18809 pubmed publisher
Nasrollahi S, Pathak A. Topographic confinement of epithelial clusters induces epithelial-to-mesenchymal transition in compliant matrices. Sci Rep. 2016;6:18831 pubmed publisher
Robinson S, Guyon L, Nevalainen J, Toriseva M, Akerfelt M, Nees M. Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields. PLoS ONE. 2015;10:e0143798 pubmed publisher
Carrim N, Arthur J, Hamilton J, Gardiner E, Andrews R, Moran N, et al. Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα. Redox Biol. 2015;6:640-647 pubmed publisher
Webber P, Park C, Qui M, Ramalingam S, Khuri F, Fu H, et al. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience. 2015;2:765-776 pubmed
Ji J, Jia S, Jia Y, Ji K, Hargest R, Jiang W. WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways. Br J Cancer. 2015;113:921-33 pubmed publisher
Zhang W, Xu C, Tu H, Wang Y, Sun Q, Hu P, et al. GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Sci Rep. 2015;5:10468 pubmed publisher
Cheng L, Sullivan B, Retana L, Allen C, Liang H, Locksley R. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015;212:513-24 pubmed publisher
Zhang F, Hao F, An D, Zeng L, Wang Y, Xu X, et al. The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration. J Biol Chem. 2015;290:8232-42 pubmed publisher
Gu Y, SHEA J, Slattum G, Firpo M, Alexander M, Mulvihill S, et al. Defective apical extrusion signaling contributes to aggressive tumor hallmarks. elife. 2015;4:e04069 pubmed publisher
Wrighton P, Klim J, Hernandez B, Koonce C, Kamp T, Kiessling L. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins. Proc Natl Acad Sci U S A. 2014;111:18126-31 pubmed publisher
Carrim N, Walsh T, Consonni A, Torti M, Berndt M, Metharom P. Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation. PLoS ONE. 2014;9:e113679 pubmed publisher
Alao J, Michlikova S, Dinér P, Grøtli M, Sunnerhagen P. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014;14:853 pubmed publisher
Williams K, Bundred N, Landberg G, Clarke R, Farnie G. Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy. Stem Cells. 2015;33:327-41 pubmed publisher
Deevi R, Cox O, O Connor R. Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the ?1-integrin-RhoA signaling axis. Neoplasia. 2014;16:422-31 pubmed publisher
Flannagan R, Canton J, Furuya W, Glogauer M, Grinstein S. The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis. Mol Biol Cell. 2014;25:1511-22 pubmed publisher
Shih C, Lacagnina M, Leuer Bisciotti K, Proschel C. Astroglial-derived periostin promotes axonal regeneration after spinal cord injury. J Neurosci. 2014;34:2438-43 pubmed publisher
Löffek S, Hurskainen T, Jackow J, Sigloch F, Schilling O, Tasanen K, et al. Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling. PLoS ONE. 2014;9:e87263 pubmed publisher
Beauséjour M, Thibodeau S, Demers M, Bouchard V, Gauthier R, Beaulieu J, et al. Suppression of anoikis in human intestinal epithelial cells: differentiation state-selective roles of ?2?1, ?3?1, ?5?1, and ?6?4 integrins. BMC Cell Biol. 2013;14:53 pubmed publisher
Yamashita O, Yoshimura K, Nagasawa A, Ueda K, Morikage N, Ikeda Y, et al. Periostin links mechanical strain to inflammation in abdominal aortic aneurysm. PLoS ONE. 2013;8:e79753 pubmed publisher
Mitrugno A, Williams D, Kerrigan S, Moran N. A novel and essential role for Fc?RIIa in cancer cell-induced platelet activation. Blood. 2014;123:249-60 pubmed publisher
Chapman N, Connolly S, Reinl E, Houtman J. Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor. J Immunol. 2013;191:6208-21 pubmed publisher
Wiel C, Augert A, Vincent D, Gitenay D, Vindrieux D, Le Calve B, et al. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death Dis. 2013;4:e855 pubmed publisher
Keasey M, Kang S, Lovins C, Hagg T. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal. 2013;11:35 pubmed publisher
Garrison G, Huang S, Okunishi K, Scott J, Kumar Penke L, Scruggs A, et al. Reversal of myofibroblast differentiation by prostaglandin E(2). Am J Respir Cell Mol Biol. 2013;48:550-8 pubmed publisher
Barbelanne M, Song J, Ahmadzai M, Tsang W. Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis. Hum Mol Genet. 2013;22:2482-94 pubmed publisher
Quint P, Ruan M, Pederson L, Kassem M, Westendorf J, Khosla S, et al. Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways. J Biol Chem. 2013;288:5398-406 pubmed publisher
Chu M, Koshman Y, Iyengar R, Kim T, Russell B, Samarel A. Contractile Activity Regulates Inducible Nitric Oxide Synthase Expression and NO(i) Production in Cardiomyocytes via a FAK-Dependent Signaling Pathway. J Signal Transduct. 2012;2012:473410 pubmed publisher
Zhang W, Huang Y, Gunst S. The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane adhesion sites. J Biol Chem. 2012;287:33996-4008 pubmed publisher
Thom S, Bhopale V, Milovanova T, Yang M, Bogush M. Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil ?(2) integrin function. J Biol Chem. 2012;287:30346-57 pubmed publisher
Despeaux M, Chicanne G, Rouer E, De Toni Costes F, Bertrand J, Mansat De Mas V, et al. Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. Stem Cells. 2012;30:1597-610 pubmed publisher
Pignatelli J, Tumbarello D, Schmidt R, Turner C. Hic-5 promotes invadopodia formation and invasion during TGF-?-induced epithelial-mesenchymal transition. J Cell Biol. 2012;197:421-37 pubmed publisher
Ho B, Olson G, Figel S, Gelman I, Cance W, Golubovskaya V. Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated. J Biol Chem. 2012;287:18656-73 pubmed publisher
Curtis M, Budyn E, Desai T, Samarel A, Russell B. Microdomain heterogeneity in 3D affects the mechanics of neonatal cardiac myocyte contraction. Biomech Model Mechanobiol. 2013;12:95-109 pubmed publisher
Beauséjour M, Noël D, Thibodeau S, Bouchard V, Harnois C, Beaulieu J, et al. Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis. 2012;17:566-78 pubmed publisher
Guessous F, Yang Y, Johnson E, Marcinkiewicz L, Smith M, Zhang Y, et al. Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy. Mol Cancer Ther. 2012;11:288-97 pubmed publisher
Wong V, Rustad K, Akaishi S, Sorkin M, Glotzbach J, Januszyk M, et al. Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat Med. 2011;18:148-52 pubmed publisher
Daley W, Kohn J, Larsen M. A focal adhesion protein-based mechanochemical checkpoint regulates cleft progression during branching morphogenesis. Dev Dyn. 2011;240:2069-83 pubmed publisher
Huang C, Park C, Hilsenbeck S, Ward R, Rimawi M, Wang Y, et al. β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. Breast Cancer Res. 2011;13:R84 pubmed publisher
Canonici A, Siret C, Pellegrino E, Pontier Bres R, Pouyet L, Montero M, et al. Saccharomyces boulardii improves intestinal cell restitution through activation of the ?2?1 integrin collagen receptor. PLoS ONE. 2011;6:e18427 pubmed publisher
Schrader J, Gordon Walker T, Aucott R, van Deemter M, Quaas A, Walsh S, et al. Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology. 2011;53:1192-205 pubmed publisher
Ocak S, Yamashita H, Udyavar A, Miller A, Gonzalez A, Zou Y, et al. DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway. Oncogene. 2010;29:6331-42 pubmed publisher
Hao S, Shen H, Hou Y, Mars W, Liu Y. tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling. Am J Pathol. 2010;177:1164-75 pubmed publisher
Tu H, Xu C, Zhang W, Liu Q, Rondard P, Pin J, et al. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci. 2010;30:749-59 pubmed publisher
Jones M, Shawe Taylor A, Williams C, Poole A. Characterization of a novel focal adhesion kinase inhibitor in human platelets. Biochem Biophys Res Commun. 2009;389:198-203 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3239
SKU :
3239/10
product name :
PF 573228
description :
Potent and selective FAK inhibitor
target :
Focal Adhesion Kinase Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at +4°C
observed molecular weight :
491.49
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM). Displays 50 - 250-fold selectivity for FAK over other protein kinases. Blocks serum and fibronectin-directed migration and decreases focal adhesion turnover in vitro .
product keywords :
Potent selective FAK inhibitors inhibits Focal Adhesion Kinases PF573228 Focal Adhesion Kinase 3239,
extended description :
Potent and selective FAK inhibitor
chemical name text :
3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
formula :
C22H20F3N5O3S
formula text :
C22H20F3N5O3S
cas num :
869288-64-2
USD :
282
USD 2025 :
291 USD
product details :
Potent and selective FAK inhibitor
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK