CDPPB | Tocris Bioscience 3235/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CDPPB

catalog :

3235/10

quantity :

10 mg (also 50 mg)

price :

246 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Bellozi P, Gomes G, da Silva M, Lima I, Batista C, Carneiro Junior W, et al. A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer's disease. Neuropharmacology. 2019;160:107785 pubmed publisher
Martinez L, Gross K, Himmler B, Emmitt N, Peterson B, Zlebnik N, et al. Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5. Eneuro. 2016;3: pubmed
Vicidomini C, Ponzoni L, Lim D, Schmeisser M, Reim D, Morello N, et al. Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice. Mol Psychiatry. 2017;22:689-702 pubmed publisher
Arsenault D, Coulombe K, Zhu A, Gong C, Kil K, Choi J, et al. Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. PLoS ONE. 2015;10:e0142093 pubmed publisher
Pacey L, Tharmalingam S, Hampson D. Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. J Pharmacol Exp Ther. 2011;338:897-905 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3235

SKU :

3235/10

product name :

CDPPB

description :

Positive allosteric modulator of mGlu5 receptors

target :

Group I mGluR Modulators

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

364.4

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CDPPB is a brain penetrant, selective positive allosteric modulator at the mGlu5 receptor (EC50 values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.

product keywords :

Positive allosteric modulators mGlu5 mGluR5 mGlur Group I Receptors Glutamate Metabotropic merck PAM Glutamate (Metabotropic) Group I Receptors 3235,

extended description :

Positive allosteric modulator of mGlu5 receptors

chemical name text :

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

formula :

C23H16N4O

formula text :

C23H16N4O

cas num :

781652-57-1

USD :

243

USD 2025 :

246 USD

product details :

Positive allosteric modulator of mGlu5 receptors

more info or order :

Tocris Bioscience product webpage