AGK 2 | Tocris Bioscience 3233/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AGK 2

catalog :

3233/10

quantity :

10 mg (also 50 mg)

price :

203 USD

citations: 3

Reference
Newton K, Hildebrand J, Shen Z, Rodriguez D, Alvarez Diaz S, Petersen S, et al. Is SIRT2 required for necroptosis?. Nature. 2014;506:E4-6 pubmed publisher
Xu Z, Ande S, Mishra S. Temporal analysis of protein lysine acetylation during adipocyte differentiation. Adipocyte. 2013;2:33-40 pubmed
Snider N, Leonard J, Kwan R, Griggs N, Rui L, Omary M. Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. J Cell Biol. 2013;200:241-7 pubmed publisher

product information

brand :

Tocris

SKU :

3233/10

product name :

AGK 2

unit sizes :

10 mg (also 50 mg)

description :

Selective SIRT2 inhibitor

target :

Class III Histone Deacetylases Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

434.27

details of functionality :

Selective inhibitor of SIRT2 (IC50 = 3.5 u M). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 u M. Reduces -synuclein-mediated toxicity in in vitro and in vivo models of Parkinson s disease.

catalog number base :

3233

extended description :

Selective SIRT2 inhibitor

chemical name text :

2-Cyano-3-[[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

formula :

C 23 H 13 Cl 2 N 3 O 2

formula text :

C23H13Cl2N3O2

cas num :

304896-28-4

USD :

203 USD

product details :

Selective SIRT2 inhibitor

storage :

Store at +4°C