bPiDDB | Tocris Bioscience 3221 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

bPiDDB

catalog :

3221

quantity :

10 mg (also 50 mg)

price :

110 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Holt J, Kewin K, Jordan P, Cameron P, Klapczynski M, McIntosh J, et al. Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents. J Neurosci. 2015;35:3625-43 pubmed publisher

product information

brand :

Tocris

master code :

3221

SKU :

3221/10

product name :

bPiDDB

description :

Orthosteric neuronal nAChR antagonist

target :

Additional Nicotinic Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

514.38

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Orthosteric neuronal nicotinic acetylcholine receptor (nAChR) antagonist (IC50 values are 0.17, 0.25, 0.4, 4.8, 6.5, 8.2, 20 and 34 M at 3 4, 1 1 , 3 4 3, 6 4 3, 7, 4 2, 3 2 3 and 6/3 2 3 receptors respectively). Attenuates nicotine-evoked dopamine release from the ventral tegmental area in vivo (IC50 = 0.2 nM) and reduces nicotine self-administration in rats. Brain penetrant.

catalog number base :

3221

product keywords :

bPiDDB nicotinic acetylcholine receptors nachrs orthosteric antagonists a3b4 alpha3beta4 3 4 brain penetrant Nicotinic Receptors (Non-selective) 3221,

extended description :

Orthosteric neuronal nAChR antagonist

chemical name text :

1,1 -(1,12-Dodecanediyl)bis[3-methylpyridinium] dibromide

formula :

C 24 H 38 Br 2 N 2

formula text :

C24H38Br2N2

cas num :

525596-66-1

2020 USD :

122

2021 USD :

110 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage