CP 376395 hydrochloride | Tocris Bioscience 3212 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CP 376395 hydrochloride

catalog :

3212

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Kean J, Bortolato A, Hollenstein K, Marshall F, Jazayeri A. Conformational thermostabilisation of corticotropin releasing factor receptor 1. Sci Rep. 2015;5:11954 pubmed publisher
Tran L, Schulkin J, Greenwood Van Meerveld B. Importance of CRF receptor-mediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain. Neuropsychopharmacology. 2014;39:2633-45 pubmed publisher
Boyson C, Holly E, Shimamoto A, Albrechet Souza L, Weiner L, DeBold J, et al. Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration. J Neurosci. 2014;34:6659-67 pubmed publisher

product information

brand :

Tocris

master code :

3212

SKU :

3212/10

product name :

CP 376395 hydrochloride

description :

Potent and selective CRF1 antagonist; binds at an allosteric site

target :

CRF1 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

362.94

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective CRF1 receptor antagonist (Ki values are 12 and 10000 nM for CRF1 and CRF2 receptors respectively). Binds at an allosteric site. Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active.

catalog number base :

3212

product keywords :

Potent selective CRF1 antagonists Corticotropin-Releasing Factor1 Receptors CP376395 hydrochloride negative allosteric modulator NAM CRF1 Receptors 3212,

extended description :

Potent and selective CRF1 antagonist; binds at an allosteric site

chemical name text :

N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride

formula :

C 21 H 30 N 2 O.HCl

formula text :

C21H30N2O.HCl

cas num :

1013933-37-3

2020 USD :

214

2021 USD :

219 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage