SB 525334 | Tocris Bioscience 3211/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 525334

catalog :

3211/10

quantity :

10 mg (also 50 mg)

price :

295 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Kilari S, Yang B, Sharma A, McCall D, Misra S. Increased transforming growth factor beta (TGF-Î²) and pSMAD3 signaling in a Murine Model for Contrast Induced Kidney Injury. Sci Rep. 2018;8:6630 pubmed publisher
Zhou X, Geng L, Wang D, Yi H, Talmon G, Wang J. R-Spondin1/LGR5 Activates TGFβ Signaling and Suppresses Colon Cancer Metastasis. Cancer Res. 2017;77:6589-6602 pubmed publisher
GutiÃ©rrez J, Droppelmann C, Contreras O, Takahashi C, Brandan E. RECK-Mediated Î²1-Integrin Regulation by TGF-Î²1 Is Critical for Wound Contraction in Mice. PLoS ONE. 2015;10:e0135005 pubmed publisher
Kleczko E, Kim J, Keysar S, Heasley L, Eagles J, Simon M, et al. An Inducible TGF-?2-TGF?R Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases. PLoS ONE. 2015;10:e0123600 pubmed publisher
Grygielewicz P, Dymek B, Bujak A, Gunerka P, Stanczak A, Lamparska Przybysz M, et al. Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells. Gastric Cancer. 2016;19:53-62 pubmed publisher
Denby L, Ramdas V, Lu R, Conway B, Grant J, Dickinson B, et al. MicroRNA-214 antagonism protects against renal fibrosis. J Am Soc Nephrol. 2014;25:65-80 pubmed publisher
Wu Y, Chang T, Huang Y, Huang H, Chou C. COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer. Oncogene. 2014;33:3432-40 pubmed publisher
Li C, Wood D, Huang J, Bhatia S. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. Lab Chip. 2013;13:1969-78 pubmed publisher
Ng F, Toh T, Ting E, Koh G, Sandanaraj E, Phong M, et al. Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors. Clin Cancer Res. 2012;18:4122-35 pubmed

image

image 1 :

Cat.No. 3211 - SB 525334 C21H21N5 CAS No. 356559-20-1

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3211

SKU :

3211/10

product name :

SB 525334

description :

Selective inhibitor of TGF- RI

target :

TGF-beta Receptor Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

97%

storage :

Store at -20°C

observed molecular weight :

343.42

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 525334 is a selective inhibitor of transforming growth factor- receptor I (ALK5, TGF- RI) (IC50 = 14.3 nM). Inhibits TGF- 1-induced smad2/3 nuclear localization and TGF- RI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.

product keywords :

Selective inhibitors inhibits TGF- RI TGF- TGF-betaRI TGFbRI TGFbR1 tgf-b1Transforming Growth Factors Beta Receptors TGF-beta Receptor Serine/Threonine Kinases RSTKs SB525334 GlaxoSmithKline GSK TGF-beta Receptors 3211,

extended description :

Selective inhibitor of TGF- RI

chemical name text :

6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline

formula :

C21H21N5

formula text :

C21H21N5

cas num :

356559-20-1

USD :

283

USD 2025 :

295 USD

product details :

Selective inhibitor of TGF- RI

more info or order :

Tocris Bioscience product webpage