product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
XAC
catalog :
3200/10
quantity :
10 mg (also 50 mg)
price :
189 USD
more info or order :
citations: 7
Reference
Canas P, Porciuncula L, Simões A, Augusto E, Silva H, Machado N, et al. Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions. Eneuro. 2018;5: pubmed publisher
Wakisaka N, Miyasaka N, Koide T, Masuda M, Hiraki Kajiyama T, Yoshihara Y. An Adenosine Receptor for Olfaction in Fish. Curr Biol. 2017;27:1437-1447.e4 pubmed publisher
Aungraheeta R, Conibear A, Butler M, Kelly E, Nylander S, Mumford A, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016;128:2717-2728 pubmed
Kaster M, Machado N, Silva H, Nunes A, Ardais A, Santana M, et al. Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress. Proc Natl Acad Sci U S A. 2015;112:7833-8 pubmed publisher
Stoddart L, Johnstone E, Wheal A, Goulding J, Robers M, Machleidt T, et al. Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 2015;12:661-663 pubmed publisher
Kozma E, Gizewski E, Tosh D, Squarcialupi L, Auchampach J, Jacobson K. Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol. 2013;85:1171-81 pubmed publisher
Sousa V, Assaife Lopes N, Ribeiro J, Pratt J, Brett R, Sebastião A. Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of ?9-tetrahydrocannabinol on spatial memory. Neuropsychopharmacology. 2011;36:472-87 pubmed publisher
image
image 1 :
Tocris Bioscience 3200/10 image 1
Cat.No. 3200 - XAC C21H28N6O4.2HCl CAS No. 1962928-23-9
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3200
SKU :
3200/10
product name :
XAC
description :
Adenosine receptor antagonist
target :
Non-selective Adenosine Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Desiccate at RT
observed molecular weight :
501.41
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
XAC is an adenosine receptor antagonist (IC50 values are 1.8 and 114 nM at A1 and A2 receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo .
product keywords :
adenosine receptors antagonists A1 A2 non-selective xanthene amine congener Xanthine amine congener Non-selective Adenosine 3200,
extended description :
Adenosine receptor antagonist
chemical name text :
N-(2-Aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide dihydrochloride
formula :
C21H28N6O4.2HCl
formula text :
C21H28N6O4.2HCl
cas num :
1962928-23-9
USD :
187
USD 2025 :
189 USD
product details :
Adenosine receptor antagonist
alt names :
Xanthine amine congener
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK