PSB 603 | Tocris Bioscience 3198/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PSB 603

catalog :

3198/10

quantity :

10 mg (also 50 mg)

price :

277 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Kang H, Shih Y, Nakasaki M, Kabra H, Varghese S. Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts. Sci Adv. 2016;2:e1600691 pubmed publisher
Rao V, Shih Y, Kang H, Kabra H, Varghese S. Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices. Front Bioeng Biotechnol. 2015;3:185 pubmed publisher
Schneider G, Glaser T, Lameu C, Abdelbaset Ismail A, Sellers Z, Moniuszko M, et al. Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Mol Cancer. 2015;14:201 pubmed publisher
Stoddart L, Johnstone E, Wheal A, Goulding J, Robers M, Machleidt T, et al. Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 2015;12:661-663 pubmed publisher
Long J, Schoonen P, Graczyk D, O Prey J, Ryan K. p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene. 2015;34:5152-62 pubmed publisher
Ham M, Mizumori M, Watanabe C, Wang J, Inoue T, Nakano T, et al. Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. J Pharmacol Exp Ther. 2010;335:607-13 pubmed publisher

product information

brand :

Tocris

catalog number base :

3198

SKU :

3198/10

product name :

PSB 603

units size :

10 mg (also 50 mg)

description :

Highly selective A2B antagonist

target :

Adenosine A2b Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

529.01

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PSB 603 is an adenosine A2B receptor antagonist that displays 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, 10000, 10000 and 10000 nM for A2B, A1, A2A and A3 receptors respectively). Downregulates the expression of osteocalcin and osteopontin during osteogenic differentiation of mesenchymal stem cells.

top caption :

Highly selective A2B antagonist

extended description :

Highly selective A2B antagonist

chemical name text :

8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine

formula :

C24H25ClN6O4S

formula text :

C24H25ClN6O4S

cas num :

1092351-10-4

USD :

277 USD

product details :

Highly selective A2B antagonist

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage