product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
BIO
catalog :
3194
quantity :
10 mg (also 50 mg)
price :
184 USD
more info or order :
citations: 18
Reference
Fleskens V, Minutti C, Wu X, Wei P, Pals C, McCrae J, et al. Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells. Cell Rep. 2019;26:3600-3612.e6 pubmed publisher
Volpini X, Ambrosio L, Fozzatti L, Insfrán C, Stempin C, Cervi L, et al. Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages. Front Immunol. 2018;9:859 pubmed publisher
Roy S, Williams V, Pipalia T, Li K, Hammond C, Knappe S, et al. Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration. Dev Biol. 2017;431:321-335 pubmed publisher
Diamantopoulou Z, White G, Fadlullah M, Dreger M, Pickering K, Maltas J, et al. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell. 2017;31:621-634.e6 pubmed publisher
Stevens M, Chaturvedi P, Rankin S, MacDonald M, Jagannathan S, Yukawa M, et al. Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs. Development. 2017;144:1283-1295 pubmed publisher
Duffy D, Krstic A, Schwarzl T, Halasz M, Iljin K, Fey D, et al. Wnt signalling is a bi-directional vulnerability of cancer cells. Oncotarget. 2016;7:60310-60331 pubmed publisher
Rhim J, Luo X, Xu X, Gao D, Zhou T, Li F, et al. A High-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells. Sci Rep. 2015;5:16237 pubmed publisher
Pronobis M, Rusan N, Peifer M. A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction. elife. 2015;4:e08022 pubmed publisher
Zhang B, Zhang T, Wang G, Wang G, Chi W, Jiang Q, et al. GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. PLoS Biol. 2015;13:e1002129 pubmed publisher
Lindström N, Lawrence M, Burn S, Johansson J, Bakker E, Ridgway R, et al. Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron. elife. 2015;3:e04000 pubmed publisher
Efthymiou A, Steiner J, Pavan W, Wincovitch S, Larson D, Porter F, et al. Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. Stem Cells Transl Med. 2015;4:230-8 pubmed publisher
Penas C, Mishra J, Wood S, Schürer S, Roush W, Ayad N. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Cell Cycle. 2015;14:417-24 pubmed publisher
Thorne C, Wichaidit C, Coster A, Posner B, Wu L, Altschuler S. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2015;11:58-63 pubmed publisher
Lu F, Sun Y, Wei C, Thisse C, Thisse B. Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nat Commun. 2014;5:5368 pubmed publisher
Naujok O, Lentes J, Diekmann U, Davenport C, Lenzen S. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res Notes. 2014;7:273 pubmed publisher
Duffy D, Krstic A, Schwarzl T, Higgins D, Kolch W. GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell viability through multiple mechanisms, including p53 and Wnt signaling. Mol Cancer Ther. 2014;13:454-67 pubmed publisher
Berger A, Hoelbl Kovacic A, Bourgeais J, Hoefling L, Warsch W, Grundschober E, et al. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia. 2014;28:629-41 pubmed publisher
Guo W, Keckesova Z, Donaher J, Shibue T, Tischler V, Reinhardt F, et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 2012;148:1015-28 pubmed publisher
product information
brand :
Tocris
master code :
3194
SKU :
3194/10
product name :
BIO
description :
Potent GSK-3 inhibitor; also inhibits cdks
target :
GSK-3 Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
356.17
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 = 5 nM). Also inhibits cyclin-dependent kinases (cdks; IC50 values are in vitro ; also promotes proliferation and dedifferentiation in cardiomyocytes. . Negative Control also available.
catalog number base :
3194
product keywords :
Potent selective GSK-3 inhibitors inhibits Glycogen Synthase Kinases 3 Carbohydrate Metabolism stem cells 6BIO Glycogen Synthase Kinase 3 Glycogen Synthase Kinase Stem Cell Proliferation Stem Cell Signaling Cyclin-dependent Kinase 3194,
extended description :
Potent GSK-3 inhibitor; also inhibits cdks
chemical name text :
(2 Z,3 E)-6-Bromoindirubin-3 -oxime
formula :
C 16 H 10 BrN 3 O 2
formula text :
C16H10BrN3O2
cas num :
667463-62-9
2020 USD :
176
2021 USD :
184 USD
alt names :
6BIO
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK