BIO | Tocris Bioscience 3194/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIO

catalog :

3194/10

quantity :

10 mg (also 50 mg)

price :

236 USD

more info or order :

Tocris Bioscience product webpage

citations: 21

Reference
Fleskens V, Minutti C, Wu X, Wei P, Pals C, McCrae J, et al. Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells. Cell Rep. 2019;26:3600-3612.e6 pubmed publisher
Volpini X, Ambrosio L, Fozzatti L, Insfrán C, Stempin C, Cervi L, et al. Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages. Front Immunol. 2018;9:859 pubmed publisher
Roy S, Williams V, Pipalia T, Li K, Hammond C, Knappe S, et al. Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration. Dev Biol. 2017;431:321-335 pubmed publisher
Diamantopoulou Z, White G, Fadlullah M, Dreger M, Pickering K, Maltas J, et al. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell. 2017;31:621-634.e6 pubmed publisher
Stevens M, Chaturvedi P, Rankin S, MacDonald M, Jagannathan S, Yukawa M, et al. Genomic integration of Wnt/Î²-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs. Development. 2017;144:1283-1295 pubmed publisher
Duffy D, Krstic A, Schwarzl T, Halasz M, Iljin K, Fey D, et al. Wnt signalling is a bi-directional vulnerability of cancer cells. Oncotarget. 2016;7:60310-60331 pubmed publisher
Rhim J, Luo X, Xu X, Gao D, Zhou T, Li F, et al. A High-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells. Sci Rep. 2015;5:16237 pubmed publisher
Pronobis M, Rusan N, Peifer M. A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient Î²catenin destruction. elife. 2015;4:e08022 pubmed publisher
Zhang B, Zhang T, Wang G, Wang G, Chi W, Jiang Q, et al. GSK3Î²-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. PLoS Biol. 2015;13:e1002129 pubmed publisher
Lindström N, Lawrence M, Burn S, Johansson J, Bakker E, Ridgway R, et al. Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron. elife. 2015;3:e04000 pubmed publisher
Efthymiou A, Steiner J, Pavan W, Wincovitch S, Larson D, Porter F, et al. Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. Stem Cells Transl Med. 2015;4:230-8 pubmed publisher
Penas C, Mishra J, Wood S, SchÃ¼rer S, Roush W, Ayad N. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Cell Cycle. 2015;14:417-24 pubmed publisher
Thorne C, Wichaidit C, Coster A, Posner B, Wu L, Altschuler S. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2015;11:58-63 pubmed publisher
Lu F, Sun Y, Wei C, Thisse C, Thisse B. Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nat Commun. 2014;5:5368 pubmed publisher
Naujok O, Lentes J, Diekmann U, Davenport C, Lenzen S. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res Notes. 2014;7:273 pubmed publisher
Li L, Kim H, Nellore A, Patsoukis N, Petkova V, McDonough S, et al. Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/?-catenin pathway and alters immune reconstitution after UCBT. Blood Cancer J. 2014;4:e178 pubmed publisher
Duffy D, Krstic A, Schwarzl T, Higgins D, Kolch W. GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell viability through multiple mechanisms, including p53 and Wnt signaling. Mol Cancer Ther. 2014;13:454-67 pubmed publisher
Berger A, Hoelbl Kovacic A, Bourgeais J, Hoefling L, Warsch W, Grundschober E, et al. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia. 2014;28:629-41 pubmed publisher
Dumollard R, Hebras C, Besnardeau L, McDougall A. Beta-catenin patterns the cell cycle during maternal-to-zygotic transition in urochordate embryos. Dev Biol. 2013;384:331-42 pubmed publisher
Guo W, Keckesova Z, Donaher J, Shibue T, Tischler V, Reinhardt F, et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 2012;148:1015-28 pubmed publisher
Gupta K, Gulen F, Sun L, Aguilera R, Chakrabarti A, Kiselar J, et al. GSK3 is a regulator of RAR-mediated differentiation. Leukemia. 2012;26:1277-85 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3194

SKU :

3194/10

product name :

BIO

description :

Potent GSK-3 inhibitor; also inhibits cdks

target :

GSK-3 Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

356.17

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BIO is a potent ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 = 5 nM). Also inhibits cyclin-dependent kinases (cdks; IC50 values are in vitro ; also promotes proliferation and dedifferentiation in cardiomyocytes. . Negative Control also available.

product keywords :

Potent selective GSK-3 inhibitors inhibits Glycogen Synthase Kinases 3 Carbohydrate Metabolism stem cells hematopoietic haematopoietic stem cells HSC 6BIO Glycogen Synthase Kinase 3 Glycogen Synthase Kinase Stem Cell Proliferation Stem Cell Signaling Non-selective CDKs Hematopoietic Stem Cells 3194,

extended description :

Potent GSK-3 inhibitor; also inhibits cdks

chemical name text :

(2 Z,3 E)-6-Bromoindirubin-3 -oxime

formula :

C16H10BrN3O2

formula text :

C16H10BrN3O2

cas num :

667463-62-9

USD :

229

USD 2025 :

236 USD

product details :

Potent GSK-3 inhibitor; also inhibits cdks

alt names :

6BIO

more info or order :

Tocris Bioscience product webpage