GANT 61 | Tocris Bioscience 3191/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GANT 61

catalog :

3191/10

quantity :

10 mg (also 50 mg)

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Calcaterra A, Iovine V, Botta B, Quaglio D, D Acquarica I, Ciogli A, et al. Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61. J Enzyme Inhib Med Chem. 2018;33:349-358 pubmed publisher
Oladapo H, Tarpley M, Sauer S, Addo K, Ingram S, Strepay D, et al. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett. 2017;411:136-149 pubmed publisher
Todd L, Fischer A. Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina. Development. 2015;142:2610-22 pubmed publisher
Wellbrock J, Latuske E, KÃ¶hler J, Wagner K, Stamm H, Vettorazzi E, et al. Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects. Clin Cancer Res. 2015;21:2388-98 pubmed publisher
Lim C, PrÃªle C, Baltic S, Arthur P, Creaney J, Watkins D, et al. Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis. Oncotarget. 2015;6:1519-30 pubmed
Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton J. Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res. 2011;71:5904-14 pubmed publisher

product information

brand :

Tocris

master code :

3191

SKU :

3191/10

rank :

0.071

product name :

GANT 61

description :

GLI antagonist; inhibits Hedgehog (Hh) signaling

target :

Hedgehog Signaling Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GANT 61 is a GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC50 ~ 5 M). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo . Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells.

extended description :

GLI antagonist; inhibits Hedgehog (Hh) signaling

chemical name text :

2,2 -[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

formula :

C 27 H 35 N 5

formula text :

C27H35N5

cas num :

500579-04-4

USD :

214 USD

product details :

GLI antagonist; inhibits Hedgehog (Hh) signaling

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage