Mirin | Tocris Bioscience 3190/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Mirin

catalog :

3190/10

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Hollingworth R, Horniblow R, Forrest C, Stewart G, Grand R. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2017;91: pubmed publisher
Berte N, PiÃ©e Staffa A, Piecha N, Wang M, Borgmann K, Kaina B, et al. Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs. Mol Cancer Ther. 2016;15:2665-2678 pubmed
Hampp S, Kiessling T, Buechle K, Mansilla S, Thomale J, Rall M, et al. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016;113:E4311-9 pubmed publisher
Lee J, Dunphy W. The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Mol Biol Cell. 2013;24:1343-53 pubmed publisher
Bothmer A, Rommel P, Gazumyan A, Polato F, Reczek C, Muellenbeck M, et al. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med. 2013;210:115-23 pubmed publisher

product information

brand :

Tocris

catalog number base :

3190

SKU :

3190/10

product name :

Mirin

units size :

10 mg (also 50 mg)

description :

MRN-ATM pathway inhibitor

target :

Checkpoint Control Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

220.25

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Mirin is a Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3 and 5 exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 M) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro .

top caption :

MRN-ATM pathway inhibitor

extended description :

MRN-ATM pathway inhibitor

chemical name text :

Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one

formula :

C10H8N2O2S

formula text :

C10H8N2O2S

cas num :

1198097-97-0

USD :

216 USD

product details :

MRN-ATM pathway inhibitor

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage