Mirin | Tocris Bioscience 3190/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Mirin

catalog :

3190/10

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Hollingworth R, Horniblow R, Forrest C, Stewart G, Grand R. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2017;91: pubmed publisher
Berte N, PiÃ©e Staffa A, Piecha N, Wang M, Borgmann K, Kaina B, et al. Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs. Mol Cancer Ther. 2016;15:2665-2678 pubmed
Hampp S, Kiessling T, Buechle K, Mansilla S, Thomale J, Rall M, et al. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016;113:E4311-9 pubmed publisher
Lee J, Dunphy W. The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Mol Biol Cell. 2013;24:1343-53 pubmed publisher
Bothmer A, Rommel P, Gazumyan A, Polato F, Reczek C, Muellenbeck M, et al. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med. 2013;210:115-23 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3190

SKU :

3190/10

product name :

Mirin

description :

MRN-ATM pathway inhibitor

target :

Checkpoint Control Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

220.25

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Mirin is a Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3 and 5 exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 M) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro .

product keywords :

MRN-ATM pathway inhibitors inhibits exonuclease activity Mre11-Rad50-Nbs1 Esterases ATM activation Checkpoint Control Kinases ATM & ATR Kinase Exonucleases 3190,

extended description :

MRN-ATM pathway inhibitor

chemical name text :

Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one

formula :

C10H8N2O2S

formula text :

C10H8N2O2S

cas num :

1198097-97-0

USD :

213

USD 2025 :

216 USD

product details :

MRN-ATM pathway inhibitor

more info or order :

Tocris Bioscience product webpage