L-779,450 | Tocris Bioscience 3185/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-779,450

catalog :

3185/10

quantity :

10 mg

price :

185 USD

product information

CHEMISTRY :

ClC(C(O)=C4)=CC=C4C(N=C(C3=CC=CC=C3)N2)=C2C1=CC=NC=C1

Stock Reference :

3185/10

Cat Number :

3185

Product Name :

L-779,450

Cas Number :

[303727-31-3]

Unit Size :

10 mg

Size :

Unit :

USD :

185 USD

Primary Category :

Enzymes

Secondary Category :

Kinases

Tertiary Category :

Raf Kinase

Primary Action :

Potent Raf kinase inhibitor

Biological Description :

Potent, ATP-competitive Raf kinase inhibitor (IC50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.

Storage :

Store at +4°C

Formula :

C20H14ClN3O

Molwt :

347.8

Minimum Purity :

> 99%

Solubility :

Soluble to 100 mM in DMSO and to 100 mM in ethanol