PHA 767491 hydrochloride | Tocris Bioscience 3140/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PHA 767491 hydrochloride

catalog :

3140/10

quantity :

10 mg (also 50 mg)

price :

175 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Bartley C, O Keefe R, Blice Baum A, Mihailescu M, Gong X, Miyares L, et al. Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP. Eneuro. 2016;3: pubmed
Wu K, Wang G, FitzGerald J, Quachthithu H, Rainey M, Cattaneo A, et al. DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach. Nucleic Acids Res. 2016;44:8786-8798 pubmed
FitzGerald J, Murillo L, O Brien G, O Connell E, O Connor A, Wu K, et al. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS ONE. 2014;9:e98891 pubmed publisher
Liachko N, McMillan P, Guthrie C, Bird T, Leverenz J, Kraemer B. CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration. Ann Neurol. 2013;74:39-52 pubmed publisher
Gardner L, Malik R, Shimizu Y, Mullins N, ElShamy W. Geminin overexpression prevents the completion of topoisomerase II? chromosome decatenation, leading to aneuploidy in human mammary epithelial cells. Breast Cancer Res. 2011;13:R53 pubmed publisher

product information

brand :

Tocris

catalog number base :

3140

SKU :

3140/10

product name :

PHA 767491 hydrochloride

units size :

10 mg (also 50 mg)

description :

Cdk inhibitor; potently inhibits cdk9; also inhibits MK2

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

249.7

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PHA 767491 hydrochloride is an ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.034 - 0.75, 0.24 - 1.2, 0.25 - 1.1 and 0.46 - 1 M for cdk9, cdk2, cdk1 and cdk5, respectively). Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2; IC50 = 171 nM). Prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo .

top caption :

Cdk inhibitor; potently inhibits cdk9; also inhibits MK2

extended description :

Cdk inhibitor; potently inhibits cdk9; also inhibits MK2

chemical name text :

1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride

formula :

C12H11N3O.HCl

formula text :

C12H11N3O.HCl

cas num :

942425-68-5

USD :

175 USD

product details :

Cdk inhibitor; potently inhibits cdk9; also inhibits MK2

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage