PHA 568487 | Tocris Bioscience 3134/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PHA 568487

catalog :

3134/10

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Sun Y, Song D, Wang M, Chen K, Zhang T. ?7 nicotinic acetylcholine receptor agonist attenuates the cerebral injury in a rat model of cardiopulmonary bypass by activating the Akt/GSK3? pathway. Mol Med Rep. 2017;16:7979-7986 pubmed publisher
Foucault Fruchard L, Doméné A, Page G, Windsor M, Emond P, Rodrigues N, et al. Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model. Neuroscience. 2017;356:52-63 pubmed publisher
Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch L, et al. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2013;18:1481-90 pubmed publisher

product information

brand :

Tocris

catalog number base :

3134

SKU :

3134/10

product name :

PHA 568487

units size :

10 mg (also 50 mg)

description :

Selective 7 nAChR agonist

target :

Nicotinic (a7) Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

404.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PHA 568487 is an agonist of the 7 nicotinic acetylcholine receptor (Ki values are 44 and 2800 for 7 and 5-HT3 respectively, IC50 values are 100 u M for 3 4 and 1 1 respectively, and % inhibition is 1 and 5% for 4 2 and hERG respectively). Orally active and brain penetrant.

top caption :

Selective 7 nAChR agonist

extended description :

Selective 7 nAChR agonist

chemical name text :

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamide fumarate

formula :

C16H20N2O3.C4H4O4

formula text :

C16H20N2O3.C4H4O4

cas num :

527680-57-5

USD :

219 USD

product details :

Selective 7 nAChR agonist

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage