NE 100 hydrochloride | Tocris Bioscience 3133/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NE 100 hydrochloride

catalog :

3133/10

quantity :

10 mg (also 50 mg)

price :

226 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Morat xf3 X, Fern xe1 ndez Due xf1 as V, P xe9 rez Villamor P, Valle Le xf3 n M, Vela J, Merlos M, et al. Development of a Novel σ1 Receptor Biosensor Based on Its Heterodimerization with Binding Immunoglobulin Protein in Living Cells. ACS Chem Neurosci. 2023;14:2201-2207 pubmed publisher
Song L, Bekdash R, Morikawa K, Quejada J, Klein A, Aina Badejo D, et al. Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat Cardiovasc Res. 2022;1:142-156 pubmed publisher
Atzmon A, Herrero M, Sharet Eshed R, Gilad Y, Senderowitz H, Elroy Stein O. Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy. Front Mol Neurosci. 2018;11:336 pubmed publisher
Maurice T, Strehaiano M, Duhr F, Chevallier N. Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the ?1 receptor. Behav Brain Res. 2018;339:1-10 pubmed publisher
RodrÃguez MuÃ±oz M, CortÃ©s Montero E, Pozo RodrigÃ¡lvarez A, SÃ¡nchez BlÃ¡zquez P, GarzÃ³n NiÃ±o J. The ON:OFF switch, Ïƒ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Oncotarget. 2015;6:35458-77 pubmed publisher
Malik M, Rangel Barajas C, Sumien N, Su C, Singh M, Chen Z, et al. The effects of sigma (Ïƒ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. Br J Pharmacol. 2015;172:2519-31 pubmed publisher
Sánchez Blázquez P, Rodríguez Muñoz M, Herrero Labrador R, Burgueno J, Zamanillo D, Garzón J. The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Int J Neuropsychopharmacol. 2014;17:1943-55 pubmed publisher
Fishback J, Rosen A, Bhat R, McCurdy C, Matsumoto R. A 96-well filtration method for radioligand binding analysis of ? receptor ligands. J Pharm Biomed Anal. 2012;71:157-61 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3133

SKU :

3133/10

product name :

NE 100 hydrochloride

description :

Selective 1 antagonist

target :

Sigma1 Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

391.97

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NE 100 hydrochloride is a potent and selective 1 receptor antagonist (Ki = 0.86 nM) that displays 55-fold selectivity over 2 receptors and 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo . Orally active.

product keywords :

Selective 1 sigma1 antagonists Receptors NE100 Sigma1 Receptors 3133,

extended description :

Selective 1 antagonist

chemical name text :

4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride

formula :

C23H33NO2.HCl

formula text :

C23H33NO2.HCl

cas num :

149409-57-4

USD :

216

USD 2025 :

226 USD

product details :

Selective 1 antagonist

more info or order :

Tocris Bioscience product webpage