BMS CCR2 22 | Tocris Bioscience 3129 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BMS CCR2 22

catalog :

3129

quantity :

1 mg (also 10 mg, 50 mg)

price :

136 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Wang J, Seo M, Deci M, Weil B, Canty J, Nguyen J. Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction. Int J Nanomedicine. 2018;13:6441-6451 pubmed
Barzilai S, Blecher Gonen R, Barnett Itzhaki Z, Zauberman A, Lebel Haziv Y, Amit I, et al. M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration. J Leukoc Biol. 2016;99:1045-55 pubmed publisher
Volpe S, Cameroni E, Moepps B, Thelen S, Apuzzo T, Thelen M. CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS ONE. 2012;7:e37208 pubmed publisher

product information

brand :

Tocris

master code :

3129

SKU :

3129/1

product name :

BMS CCR2 22

description :

High affinity, potent CCR2 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

unit size :

1 mg (also 10 mg, 50 mg)

purity :

98%

observed molecular weight :

593.66

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.

catalog number base :

3129

product keywords :

High affinity potent CCR2 antagonists Chemokine Receptors BMSCCR222 Chemokine CC Receptors 3129,

extended description :

High affinity, potent CCR2 antagonist

chemical name text :

2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide

formula :

C 28 H 34 F 3 N 5 O 4 S

formula text :

C28H34F3N5O4S

cas num :

445479-97-0

2020 USD :

130

2021 USD :

136 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage