BMS CCR2 22 | Tocris Bioscience 3129/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BMS CCR2 22

catalog :

3129/1

quantity :

1 mg (also 10 mg, 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Wang Y, Yu L, Hu Z, Fang Y, Shen Y, Song M, et al. Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer. Cell Death Dis. 2022;13:748 pubmed publisher
Wang J, Seo M, Deci M, Weil B, Canty J, Nguyen J. Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction. Int J Nanomedicine. 2018;13:6441-6451 pubmed
Liu J, Xue Y, Dong D, Xiao C, Lin C, Wang H, et al. CCR2- and CCR2+ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion. Mucosal Immunol. 2017;10:1145-1159 pubmed publisher
Barzilai S, Blecher Gonen R, Barnett Itzhaki Z, Zauberman A, Lebel Haziv Y, Amit I, et al. M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration. J Leukoc Biol. 2016;99:1045-55 pubmed publisher
Huang C, Chen Y, Li A, Lu J, Wang H. Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons. J Neuroinflammation. 2014;11:7 pubmed publisher
Volpe S, Cameroni E, Moepps B, Thelen S, Apuzzo T, Thelen M. CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS ONE. 2012;7:e37208 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3129

SKU :

3129/1

product name :

BMS CCR2 22

description :

High affinity, potent CCR2 antagonist

target :

Chemokine Receptor Antagonists

unit size :

1 mg (also 10 mg, 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

593.66

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BMS CCR2 22 is a high affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.

product keywords :

High affinity potent CCR2 antagonists Chemokine Receptors BMSCCR222 Chemokine CC Receptors 3129,

extended description :

High affinity, potent CCR2 antagonist

chemical name text :

2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide

formula :

C28H34F3N5O4S

formula text :

C28H34F3N5O4S

cas num :

445479-97-0

USD :

171

USD 2025 :

173 USD

product details :

High affinity, potent CCR2 antagonist

more info or order :

Tocris Bioscience product webpage