Ranolazine dihydrochloride | Tocris Bioscience 3118/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ranolazine dihydrochloride

catalog :

3118/50

quantity :

50 mg

price :

167 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Carstensen H, Hesselkilde E, Haugaard M, Flethøj M, Carlson J, Pehrson S, et al. Effects of dofetilide and ranolazine on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation. J Cardiovasc Electrophysiol. 2019;30:596-606 pubmed publisher
McKeithan W, Savchenko A, YU M, Cerignoli F, Bruyneel A, Price J, et al. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017;8:766 pubmed publisher
Carstensen H, Kjær L, Haugaard M, Flethøj M, Hesselkilde E, Kanters J, et al. Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses. J Cardiovasc Pharmacol. 2018;71:26-35 pubmed publisher
Park Y, Johnston D, Gray R. Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons. J Neurophysiol. 2013;109:1378-90 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3118

SKU :

3118/50

product name :

Ranolazine dihydrochloride

description :

Antianginal, activates pyruvate dehydrogenase

target :

Dehydrogenase Activators

unit size :

50 mg

category :

Small Molecules

purity :

98%

storage :

Desiccate at RT

observed molecular weight :

500.46

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ranolazine dihydrochloride is an antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late INa and IKr currents.

product keywords :

Anti-anginal activates pyruvate dehydrogenase anti-arrhythmic agent activators Enzyme Substrates RS43285 RS 43285 Other Dehydrogenases Enzyme Substrates/ Activators Miscellaneous Compounds 3118,

extended description :

Antianginal, activates pyruvate dehydrogenase

chemical name text :

N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride

formula :

C24H33N3O4.2HCl

formula text :

C24H33N3O4.2HCl

cas num :

95635-56-6

USD :

162

USD 2025 :

167 USD

product details :

Antianginal, activates pyruvate dehydrogenase

alt names :

RS 43285

more info or order :

Tocris Bioscience product webpage