Troglitazone | Tocris Bioscience 3114/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Troglitazone

catalog :

3114/10

quantity :

10 mg (also 50 mg)

price :

191 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Ross F, Hawley S, Auciello F, Gowans G, Atrih A, Lamont D, et al. Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. Cell Chem Biol. 2017;24:813-824.e4 pubmed publisher
Bisikirska B, Bansal M, Shen Y, Teruya Feldstein J, Chaganti R, Califano A. Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res. 2016;76:664-74 pubmed publisher
Hegde V, Singh U, Nagarkatti P, Nagarkatti M. Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor Î³ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo. J Immunol. 2015;194:5211-22 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3114

SKU :

3114/10

product name :

Troglitazone

description :

Selective PPAR agonist; antidiabetic agent

target :

PPAR gamma Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

441.54

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Troglitazone is a selective PPAR receptor agonist (EC50 values are 780 and 555 nM at murine and human PPAR receptors respectively). Displays no activity at PPAR or PPAR receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.

product keywords :

Selective PPAR PPARgamma agonists antidiabetic agent Peroxisome Proliferator-activating Receptors hematopoietic haematopoietic stem cells HSC Rezulin PPARgamma Receptors Stem Cell Proliferation Hematopoietic Stem Cells 3114,

extended description :

Selective PPAR agonist; antidiabetic agent

chemical name text :

5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione

formula :

C24H27NO5S

formula text :

C24H27NO5S

cas num :

97322-87-7

USD :

189

USD 2025 :

191 USD

product details :

Selective PPAR agonist; antidiabetic agent

alt names :

Rezulin

more info or order :

Tocris Bioscience product webpage