Furosemide | Tocris Bioscience 3109 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Furosemide

catalog :

3109

quantity :

50 mg

price :

53 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Barbaro N, Foss J, Kryshtal D, Tsyba N, Kumaresan S, Xiao L, et al. Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension. Cell Rep. 2017;21:1009-1020 pubmed publisher
Li J, Casteels T, Frogne T, Ingvorsen C, Honore C, Courtney M, et al. Artemisinins Target GABAA Receptor Signaling and Impair ? Cell Identity. Cell. 2017;168:86-100.e15 pubmed publisher
Accardi M, Brown P, Miraucourt L, Orser B, Bowie D. Î±6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells. J Neurosci. 2015;35:9676-88 pubmed publisher
Choe K, Han S, Gaub P, Shell B, Voisin D, Knapp B, et al. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Neuron. 2015;85:549-60 pubmed publisher
Di Angelantonio S, Murana E, Cocco S, Scala F, Bertollini C, Molinari M, et al. A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium. Cell Death Dis. 2014;5:e1501 pubmed publisher
Deeb T, Nakamura Y, Frost G, Davies P, Moss S. Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states. Eur J Neurosci. 2013;38:2453-67 pubmed publisher

product information

brand :

Tocris

master code :

3109

SKU :

3109/50

product name :

Furosemide

description :

Na+/2Cl-/K+ (NKCC) symporter inhibitor; also GABAA antagonist

target :

NKCC Cotransporter Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

330.74

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for 6-containing receptors than 1-containing receptors.

catalog number base :

3109

product keywords :

Na+/2Cl-/K+ NKCC1 NKCC2 cotransporters inhibitors inhibits antagonizes GABAA receptor antagonists blockers Sodium Potassium Chloride Ion Transporters Pumps Receptors diuretics Na+/K+/Cl- Symporter GABAA Receptors 3109,

extended description :

Na+/2Cl-/K+ (NKCC) symporter inhibitor; also GABAA antagonist

chemical name text :

5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid

formula :

C 12 H 11 ClN 2 O 5 S

formula text :

C12H11ClN2O5S

cas num :

54-31-9

2020 USD :

2021 USD :

53 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage