Bumetanide | Tocris Bioscience 3108/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bumetanide

catalog :

3108/50

quantity :

50 mg

price :

111 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Babola T, Kersbergen C, Wang H, Bergles D. Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. elife. 2020;9: pubmed publisher
Bhandage A, Kanatani S, Barragan A. Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling. Front Cell Infect Microbiol. 2019;9:73 pubmed publisher
Spoljaric I, Spoljaric A, Mavrovic M, Seja P, Puskarjov M, Kaila K. KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice. Cell Rep. 2019;26:1073-1081.e3 pubmed publisher
Kanagaratnam M, Pendleton C, Souza D, Pettit J, Howells J, Baker M. Diuretic-sensitive electroneutral Na+ movement and temperature effects on central axons. J Physiol. 2017;595:3471-3482 pubmed publisher
Alfonsa H, Lakey J, Lightowlers R, Trevelyan A. Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons. Nat Commun. 2016;7:13495 pubmed publisher
PÃ¡l I, Kardos J, Dobolyi Ã, HÃ©ja L. Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Mol Brain. 2015;8:35 pubmed publisher
Choe K, Han S, Gaub P, Shell B, Voisin D, Knapp B, et al. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Neuron. 2015;85:549-60 pubmed publisher
Di Angelantonio S, Murana E, Cocco S, Scala F, Bertollini C, Molinari M, et al. A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium. Cell Death Dis. 2014;5:e1501 pubmed publisher
Deeb T, Nakamura Y, Frost G, Davies P, Moss S. Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states. Eur J Neurosci. 2013;38:2453-67 pubmed publisher
Shulga A, Magalhães A, Autio H, Plantman S, Di Lieto A, Nykjær A, et al. The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci. 2012;32:1757-70 pubmed publisher
Haam J, Popescu I, Morton L, Halmos K, Teruyama R, Ueta Y, et al. GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci. 2012;32:572-82 pubmed publisher
Safiulina V, Zacchi P, Taglialatela M, Yaari Y, Cherubini E. Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus. J Physiol. 2008;586:5437-53 pubmed publisher
Shulga A, Thomas Crusells J, Sigl T, Blaesse A, Mestres P, Meyer M, et al. Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons. J Neurosci. 2008;28:6996-7005 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3108

SKU :

3108/50

product name :

Bumetanide

description :

Na+/2Cl-/K+ (NKCC) symporter inhibitor

target :

NKCC Cotransporter Inhibitors

unit size :

50 mg

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

364.42

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Bumetanide is a loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109). Bumetanide improves electrophysiological, pathological and cognitive deficits in APOE4 knock-in mice. RNA sequencing of neurons derived from APOE4 induced pluripotent stem cell (iPSC) shows Bumetanide reverses Alzheimer s disease transcriptomic signatures.

product keywords :

Na+/2Cl-/K+ NKCC1 NKCC2 cotransporter inhibitors inhibits Sodium Potassium Chloride Cotransporters Ion Pumps APOE4 alzheimer Alzheimer s disease Na+/K+/Cl- Symporter 3108,

extended description :

Na+/2Cl-/K+ (NKCC) symporter inhibitor

chemical name text :

3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid

formula :

C17H20N2O5S

formula text :

C17H20N2O5S

cas num :

28395-03-1

USD :

109

USD 2025 :

111 USD

product details :

Na+/2Cl-/K+ (NKCC) symporter inhibitor

more info or order :

Tocris Bioscience product webpage