NBI 35965 hydrochloride | Tocris Bioscience 3100/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NBI 35965 hydrochloride

catalog :

3100/10

quantity :

10 mg (also 50 mg)

price :

273 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Martinon D, Dabrowska J. Corticotropin-Releasing Factor Receptors Modulate Oxytocin Release in the Dorsolateral Bed Nucleus of the Stria Terminalis (BNST) in Male Rats. Front Neurosci. 2018;12:183 pubmed publisher
Abdelhamid R, Kovács K, Pasley J, Nunez M, Larson A. Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors. Neuropharmacology. 2013;72:29-37 pubmed publisher

product information

brand :

Tocris

master code :

3100

SKU :

3100/10

product name :

NBI 35965 hydrochloride

description :

Potent and selective CRF1 antagonist

target :

CRF1 Receptor Antagonists

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

437.79

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NBI 35965 hydrochloride is a potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist (Ki values are 4 and 10000 nM at CRF1 and CRF2 respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50 values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo . Orally active and brain penetrant with anxiolytic activity.

extended description :

Potent and selective CRF1 antagonist

chemical name text :

(7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride

formula :

C 21 H 22 Cl 2 N 4 .HCl

formula text :

C21H22Cl2N4.HCl

cas num :

1782228-59-4

USD :

273 USD

product details :

Potent and selective CRF1 antagonist

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage