product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
Pertussis Toxin
catalog :
3097/50U
quantity :
50 ug
price :
467 USD
more info or order :
citations: 21
Reference
Hu X, Zou Y, Copland D, Schewitz Bowers L, Li Y, Lait P, et al. Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2. EBioMedicine. 2022;86:104333 pubmed publisher
Wyant G, Yu W, Doulamis I, Nomoto R, Saeed M, Duignan T, et al. Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists. Science. 2022;377:621-629 pubmed publisher
Zhao P, Ming Q, Qiu J, Tian D, Liu J, Shen J, et al. Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2. Molecules. 2018;23: pubmed publisher
O Neill N, Sylantyev S. Feature Article: Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C. Exp Biol Med (Maywood). 2018;243:1046-1055 pubmed publisher
Nepomuceno D, Kuei C, Dvorak C, Lovenberg T, Liu C, Bonaventure P. Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. Front Pharmacol. 2018;9:157 pubmed publisher
Li X, Chen W, Li P, Wei J, Cheng Y, Liu P, et al. Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression. Theranostics. 2017;7:4671-4688 pubmed publisher
Yuan X, Cao J, He X, Serra R, Qu J, Cao X, et al. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Nat Commun. 2016;7:11024 pubmed publisher
Sim D, Chu C, Selvam S, Powner M, Liyanage S, Copland D, et al. A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye. Dis Model Mech. 2015;8:1479-87 pubmed publisher
Jones M, Huang H, Calabresi P, Levy M. Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica. Acta Neuropathol Commun. 2015;3:28 pubmed publisher
Stott J, Povstyan O, Carr G, Barrese V, Greenwood I. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Proc Natl Acad Sci U S A. 2015;112:6497-502 pubmed publisher
Crawford G, Boldison J, Copland D, Adamson P, Gale D, Brandt M, et al. The role of lipoprotein-associated phospholipase A2 in a murine model of experimental autoimmune uveoretinitis. PLoS ONE. 2015;10:e0122093 pubmed publisher
Butschkau A, Wagner N, Genz B, Vollmar B. Protein z exerts pro-angiogenic effects and upregulates CXCR4. PLoS ONE. 2014;9:e113554 pubmed publisher
Choi D, Stark D, Raphael R, Wen J, Su J, Zhou X, et al. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. Int J Cancer. 2015;136:E219-29 pubmed publisher
Boldison J, Chu C, Copland D, Lait P, Khera T, Dick A, et al. Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis. J Immunol. 2014;192:4541-50 pubmed publisher
Rimmerman N, Ben Hail D, Porat Z, Juknat A, Kozela E, Daniels M, et al. Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death. Cell Death Dis. 2013;4:e949 pubmed publisher
Wydeven N, Young D, Mirkovic K, Wickman K. Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity. Proc Natl Acad Sci U S A. 2012;109:21492-7 pubmed publisher
Park C, Xu Z, Liu T, Lu N, Serhan C, Ji R. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. J Neurosci. 2011;31:18433-8 pubmed publisher
Cheng G, Kasiganesan H, Baicu C, Wallenborn J, Kuppuswamy D, Cooper G. Cytoskeletal role in protection of the failing heart by ?-adrenergic blockade. Am J Physiol Heart Circ Physiol. 2012;302:H675-87 pubmed publisher
Schutsky K, Ouyang M, Castelino C, Zhang L, Thomas S. Stress and glucocorticoids impair memory retrieval via ?2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci. 2011;31:14172-81 pubmed publisher
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher
Nagaraja S, Iyer S, Liu X, Eichberg J, Bond R. Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic beta2-adrenoceptor activation. Br J Pharmacol. 1999;127:1099-104 pubmed
product information
brand :
Tocris
master code :
3097
SKU :
3097/50U
product name :
Pertussis Toxin
description :
Catalyzes ADP-ribosylation of Gi, Go and Gt
target :
G Protein (Heterotrimeric) Inhibitors
category :
Small Molecules
unit sizes :
50 ug
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Pertussis Toxin is a bacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling. Pertussis Toxin protects against ischemic stroke in a mouse model of permanent middle cerebral artery occlusion. Pertussis Toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an experimental autoimmune encephalomyelitis mouse model.
extended description :
Catalyzes ADP-ribosylation of Gi, Go and Gt
cas num :
70323-44-3
USD :
467 USD
product details :
Catalyzes ADP-ribosylation of Gi, Go and Gt
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK