Flavopiridol hydrochloride | Tocris Bioscience 3094/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Flavopiridol hydrochloride

catalog :

3094/10

quantity :

10 mg (also 50 mg)

price :

250 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Stork C, Bocek M, Crossley M, Sollier J, Sanz L, Chedin F, et al. Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage. elife. 2016;5: pubmed publisher

product information

brand :

Tocris

master code :

3094

SKU :

3094/10

product name :

Flavopiridol hydrochloride

description :

Cdk inhibitor; potently inhibits cdk2 and cdk9

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

438.3

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Flavopiridol hydrochloride is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and 0.85 M for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro .

extended description :

Cdk inhibitor; potently inhibits cdk2 and cdk9

chemical name text :

2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride

formula :

C 21 H 20 ClNO 5 .HCl

formula text :

C21H20ClNO5.HCl

cas num :

131740-09-5

USD :

250 USD

product details :

Cdk inhibitor; potently inhibits cdk2 and cdk9

alt names :

L 86-8275

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage