product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Dorsomorphin dihydrochloride
catalog :
3093/10
quantity :
10 mg (also 50 mg)
price :
291 USD
more info or order :
citations: 88
Reference
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product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3093
SKU :
3093/10
product name :
Dorsomorphin dihydrochloride
description :
Potent AMPK inhibitor; also BMP type I receptor inhibitor
target :
AMPK Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Desiccate at RT
observed molecular weight :
472.41
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKC , PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and Metformin (Cat. No. 2864). Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. The compound can also be used in protocols for the chemical reprogramming of somatic cells to iPSCs.Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition. Also used in a protocol to generate brain organoids from human iPSCs.
product keywords :
Potent AMPK inhibitors inhibits BMP type I receptor ALK2 ALK3 ALK6 AMP-Activated Protein Kinases Receptors Activin Receptor-like Receptor Serine/Threonine RSTKs stem cells BML275 866405-64-3 differentiation induced pluripotent stem cells reprogramming iPS Compound C BML-275 BMP and Other Activin Receptors AMPK Autophagy Cardiomyocyte Stem Cells ESCs and iPSC Neural Stem Cells Organoids Stem Cell Reprogramming 3093,
extended description :
Potent AMPK inhibitor; also BMP type I receptor inhibitor
chemical name text :
6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
formula :
C24H25N5O.2HCl
formula text :
C24H25N5O.2HCl
cas num :
1219168-18-9
USD :
279
USD 2025 :
291 USD
product details :
Potent AMPK inhibitor; also BMP type I receptor inhibitor
alt names :
Compound C,BML-275
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK