product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PHA 543613 hydrochloride
catalog :
3092
quantity :
10 mg
price :
223 USD
more info or order :
citations: 7
Reference
Bali Z, Nagy L, Budai D, Hernadi I. Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo. Sci Rep. 2019;9:9324 pubmed publisher
Bali Z, Bruszt N, Tadepalli S, Csurgyók R, Nagy L, Tompa M, et al. Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats. Front Pharmacol. 2019;10:73 pubmed publisher
Foucault Fruchard L, Doméné A, Page G, Windsor M, Emond P, Rodrigues N, et al. Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model. Neuroscience. 2017;356:52-63 pubmed publisher
Sérrière S, Doméné A, Vercouillie J, Mothes C, Bodard S, Rodrigues N, et al. Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model. Front Med (Lausanne). 2015;2:61 pubmed publisher
Bali Z, Inkeller J, Csurgyók R, Bruszt N, Horváth H, Hernádi I. Differential effects of α7 nicotinic receptor agonist PHA-543613 on spatial memory performance of rats in two distinct pharmacological dementia models. Behav Brain Res. 2015;278:404-10 pubmed publisher
Macpherson A, Zoheir N, Awang R, Culshaw S, Ramage G, Lappin D, et al. The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes. Inflamm Res. 2014;63:557-68 pubmed publisher
Wang Q, Wang F, Li X, Yang Q, Li X, Xu N, et al. Electroacupuncture pretreatment attenuates cerebral ischemic injury through ?7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats. J Neuroinflammation. 2012;9:24 pubmed publisher
product information
brand :
Tocris
master code :
3092
SKU :
3092/10
product name :
PHA 543613 hydrochloride
description :
Potent and selective 7 nAChR agonist
target :
Nicotinic (a7) Receptor Agonists
category :
Small Molecules
unit size :
10 mg
purity :
98%
observed molecular weight :
307.78
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent 7 nAChR agonist that displays selectivity over 3 4, 1 1 , 4 2 and 5-HT3 receptors. Positively influences sensory gating and memory in in vivo models of schizophrenia. Orally active and brain penetrant.
catalog number base :
3092
product keywords :
Potent selective 7 alpha7 a7 nAChR agonists Nicotinic Receptors Acetylcholine PHA543613 hydrochloride Pfizer 478149-53-0 Nicotinic (a7) Receptors 3092,
extended description :
Potent and selective 7 nAChR agonist
chemical name text :
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride
formula :
C 15 H 17 N 3 O 2 .HCl
formula text :
C15H17N3O2.HCl
cas num :
1586767-92-1
2020 USD :
218
2021 USD :
223 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK