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company name :
Tocris Bioscience
product type :
chemical
product name :
Gallein
catalog :
3090/50
quantity :
50 mg
price :
126 USD
more info or order :
citations: 24
Reference
Cervantes Villagrana R, Color Aparicio V, Reyes Cruz G, Vazquez Prado J. Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs. J Cell Commun Signal. 2019;13:179-191 pubmed publisher
Zhao P, Ming Q, Qiu J, Tian D, Liu J, Shen J, et al. Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2. Molecules. 2018;23: pubmed publisher
Stuelten C, Lee R, Losert W, Parent C. Lysophosphatidic acid regulates the motility of MCF10CA1a breast cancer cell sheets via two opposing signaling pathways. Cell Signal. 2018;45:1-11 pubmed publisher
Cameron R, Peterson Y, Beeson C, Schnellmann R. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol. Sci Rep. 2017;7:10578 pubmed publisher
Shen Z, Chen Y, Hong L, Cui Z, Yang H, He X, et al. BNGR-A25L and -A27 are two functional G protein-coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm Bombyx mori. J Biol Chem. 2017;292:16554-16570 pubmed publisher
Travers J, Kamal F, Valiente Alandi I, Nieman M, Sargent M, Lorenz J, et al. Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression. J Am Coll Cardiol. 2017;70:958-971 pubmed publisher
Xiao L, Priest M, Nasenbeny J, Lu T, Kozorovitskiy Y. Biased Oxytocinergic Modulation of Midbrain Dopamine Systems. Neuron. 2017;95:368-384.e5 pubmed publisher
Weber L, Al Refae K, Ebbert J, Jagers P, Altmuller J, Becker C, et al. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PLoS ONE. 2017;12:e0172491 pubmed publisher
Gautam J, Banskota S, Regmi S, Ahn S, Jeon Y, Jeong H, et al. Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer. 2016;15:75 pubmed
Liu Y, Yang T, Zhao L, Ni Z, Yang N, He F, et al. Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome. Sci Rep. 2016;6:33614 pubmed publisher
Shutov L, Warwick C, Shi X, Gnanasekaran A, Shepherd A, Mohapatra D, et al. The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1. J Neurosci. 2016;36:5055-70 pubmed publisher
Pon C, Lane J, Sloan E, Halls M. The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J. 2016;30:1144-54 pubmed publisher
Stott J, Povstyan O, Carr G, Barrese V, Greenwood I. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Proc Natl Acad Sci U S A. 2015;112:6497-502 pubmed publisher
Chung J, Huber T, Gödel M, Jarad G, Hartleben B, Kwoh C, et al. Albumin-associated free fatty acids induce macropinocytosis in podocytes. J Clin Invest. 2015;125:2307-16 pubmed publisher
López Cotarelo P, Escribano Díaz C, González Bethencourt I, Gómez Moreira C, Deguiz M, Torres Bacete J, et al. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. J Biol Chem. 2015;290:827-40 pubmed publisher
Sikka G, Hussmann G, Pandey D, Cao S, Hori D, Park J, et al. Melanopsin mediates light-dependent relaxation in blood vessels. Proc Natl Acad Sci U S A. 2014;111:17977-82 pubmed publisher
Foster S, Blank K, See Hoe L, Behrens M, Meyerhof W, Peart J, et al. Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart. FASEB J. 2014;28:4497-508 pubmed publisher
Sanz G, Leray I, Dewaele A, Sobilo J, Lerondel S, Bouet S, et al. Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation. PLoS ONE. 2014;9:e85110 pubmed publisher
Salgado Pabon W, Breshears L, Spaulding A, Merriman J, Stach C, Horswill A, et al. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. MBio. 2013;4: pubmed publisher
Ahmadiantehrani S, Ron D. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via G??-Erk1/2-dependent induction of Zif268. J Neurochem. 2013;125:193-204 pubmed publisher
Breshears L, Schlievert P, Peterson M. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem. 2012;287:32578-87 pubmed
Meens M, Mattheij N, van Loenen P, Spijkers L, Lemkens P, Nelissen J, et al. G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. Br J Pharmacol. 2012;166:297-308 pubmed publisher
Ukhanov K, Brunert D, Corey E, Ache B. Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J Neurosci. 2011;31:273-80 pubmed publisher
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3090
SKU :
3090/50
product name :
Gallein
description :
Inhibitor of G / signaling
target :
G Protein (Heterotrimeric) Inhibitors
unit size :
50 mg
category :
Small Molecules
purity :
97%
storage :
Store at -20°C
observed molecular weight :
364.31
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Gallein is an inhibitor of G protein subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.
product keywords :
inhibitors inhibits betagamma signaling G Proteins Heterotrimeric Heterotrimeric G-protein GTPases 3090,
extended description :
Inhibitor of G / signaling
chemical name text :
3 ,4 ,5 ,6 -Tetrahydroxyspiro[isobenzofuran-1(3H),9 -(9H)xanthen]-3-one
formula :
C20H12O7
formula text :
C20H12O7
cas num :
2103-64-2
USD :
122
USD 2025 :
126 USD
product details :
Inhibitor of G / signaling
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK