HU 308 | Tocris Bioscience 3088 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

HU 308

catalog :

3088

quantity :

10 mg (also 50 mg)

price :

289 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Sheng W, Chauhan P, Hu S, Prasad S, Lokensgard J. Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain. Pain Res Manag. 2019;2019:1260353 pubmed publisher
Acevedo Canabal A, Colón Cruz L, Rodriguez Morales R, Varshney G, Burgess S, González Sepúlveda L, et al. Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2. Cannabis Cannabinoid Res. 2019;4:88-101 pubmed publisher
Ke P, Shao B, Xu Z, Wei W, Han B, Chen X, et al. Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages. PLoS ONE. 2016;11:e0155076 pubmed publisher
Presley C, Abidi A, Suryawanshi S, Mustafa S, Meibohm B, Moore B. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist. Pharmacol Res Perspect. 2015;3:e00159 pubmed publisher
Gianella Borradori M, Christou I, Bataille C, Cross R, Wynne G, Greaves D, et al. Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists. Bioorg Med Chem. 2015;23:241-63 pubmed publisher
Sardinha J, Kelly M, Zhou J, Lehmann C. Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Mediators Inflamm. 2014;2014:978678 pubmed publisher
Solbrig M, Fan Y, Hazelton P. Prospects for cannabinoid therapies in viral encephalitis. Brain Res. 2013;1537:273-82 pubmed publisher

product information

brand :

Tocris

master code :

3088

SKU :

3088/10

product name :

HU 308

description :

Potent and selective CB2 agonist

target :

Cannabinoid R2/CB2 Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

414.62

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective CB2 receptor agonist (Ki values are 22.7 nM and 10 M for CB2 and CB1 receptors respectively, EC50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain. Also neuroprotective and improves motor performance in a mouse model of Huntington s Disease.

catalog number base :

3088

product keywords :

Potent selective CB2 agonists cannabinoids Receptors HU308 cb2r huntingtons disease CB2 Receptors 3088,

extended description :

Potent and selective CB2 agonist

chemical name text :

4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol

formula :

C 27 H 42 O 3

formula text :

C27H42O3

cas num :

256934-39-1

2020 USD :

283

2021 USD :

289 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage