1-Naphthyl PP1 | Tocris Bioscience 3063/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1-Naphthyl PP1

catalog :

3063/10

quantity :

10 mg (also 50 mg)

price :

360 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
O Neill A, Kindberg A, Niethamer T, Larson A, Ho H, Greenberg M, et al. Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol. 2016;215:217-229 pubmed
Chen X, Suhandynata R, Sandhu R, Rockmill B, Mohibullah N, Niu H, et al. Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis. PLoS Biol. 2015;13:e1002329 pubmed publisher
Meyer R, Chuong H, Hild M, Hansen C, Kinter M, Dawson D. Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae. Mol Biol Cell. 2015;26:2986-3000 pubmed publisher
Suhandynata R, Liang J, Albuquerque C, Zhou H, Hollingsworth N. A method for sporulating budding yeast cells that allows for unbiased identification of kinase substrates using stable isotope labeling by amino acids in cell culture. G3 (Bethesda). 2014;4:2125-35 pubmed publisher
Kim S, Meyer R, Chuong H, Dawson D. Dual mechanisms prevent premature chromosome segregation during meiosis. Genes Dev. 2013;27:2139-46 pubmed publisher
Lo H, Hollingsworth N. Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1. Methods Mol Biol. 2011;745:135-49 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3063

SKU :

3063/10

product name :

1-Naphthyl PP1

description :

Src family kinase inhibitor; also inhibits c-Abl

target :

Src Family Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

317.39

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 u M for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

product keywords :

Src family kinase inhibits inhibitors c-Abl v-Src c-Fyn 1-NaphthylPP1 1NAPP1 1-NA-PP 1 Src Kinases Abl Kinase 3063,

extended description :

Src family kinase inhibitor; also inhibits c-Abl

chemical name text :

1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

formula :

C19H19N5

formula text :

C19H19N5

cas num :

221243-82-9

USD :

356

USD 2025 :

360 USD

product details :

Src family kinase inhibitor; also inhibits c-Abl

alt names :

1-NA-PP 1

more info or order :

Tocris Bioscience product webpage