Macbecin I | Tocris Bioscience 3061/1 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Macbecin I

catalog :

3061/1

quantity :

1 mg

price :

311 USD

citations: 1

Reference
Alford B, Brandman O. Quantification of Hsp90 availability reveals differential coupling to the heat shock response. J Cell Biol. 2018;217:3809-3816 pubmed publisher

product information

brand :

Tocris

MasterCode :

3061

SKU :

3061/1

product name :

Macbecin I

unit sizes :

1 mg

description :

Hsp90 inhibitor

target :

HSP90 Inhibitors

category :

Small Molecules

observed molecular weight :

558.67

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 u M) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 u M) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368).

extended description :

Hsp90 inhibitor

chemical name text :

(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin

formula :

C 30 H 42 N 2 O 8

formula text :

C30H42N2O8

cas num :

73341-72-7

USD :

311 USD

product details :

Hsp90 inhibitor

storage :

Desiccate at -20°C