PD 173074 | Tocris Bioscience 3044 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 173074

catalog :

3044

quantity :

10 mg (also 50 mg)

price :

231 USD

more info or order :

Tocris Bioscience product webpage

citations: 19

Reference
Bise T, de Preux Charles A, Jazwinska A. Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart. NPJ Regen Med. 2019;4:2 pubmed publisher
Yuan X, Cao X, Yang S. IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development. Cell Death Dis. 2019;10:63 pubmed publisher
Takata N, Sakakura E, Eiraku M, Kasukawa T, Sasai Y. Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism. Nat Commun. 2017;8:1339 pubmed publisher
Nacu E, Gromberg E, Oliveira C, Drechsel D, Tanaka E. FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration. Nature. 2016;533:407-10 pubmed publisher
Lichtenberger B, Mastrogiannaki M, Watt F. Epidermal Î²-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages. Nat Commun. 2016;7:10537 pubmed publisher
Anreddy N, Patel A, Sodani K, Kathawala R, Chen E, Wurpel J, et al. PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR. Acta Pharm Sin B. 2014;4:202-7 pubmed publisher
MacKenzie B, Korfei M, Henneke I, Sibinska Z, Tian X, Hezel S, et al. Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis. Respir Res. 2015;16:83 pubmed publisher
Yang J, Kaur K, Ong L, Eisenberg C, Eisenberg L. Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors. Stem Cells Int. 2015;2015:270428 pubmed publisher
Knuchel S, Anderle P, Werfelli P, Diamantis E, RÃ¼egg C. Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin Î±vÎ²5-mediated adhesion. Oncotarget. 2015;6:14300-17 pubmed
Benzina S, Pitaval A, Lemercier C, Lustremant C, Frouin V, Wu N, et al. A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. Cell Mol Life Sci. 2015;72:3559-73 pubmed publisher
Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, et al. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma. BMC Cancer. 2015;15:82 pubmed publisher
Witty A, Mihic A, Tam R, Fisher S, Mikryukov A, Shoichet M, et al. Generation of the epicardial lineage from human pluripotent stem cells. Nat Biotechnol. 2014;32:1026-35 pubmed publisher
Rankin S, Thi Tran H, Wlizla M, Mancini P, Shifley E, Bloor S, et al. A Molecular atlas of Xenopus respiratory system development. Dev Dyn. 2015;244:69-85 pubmed publisher
Rodriguez A, Allegrucci C, Alberio R. Modulation of pluripotency in the porcine embryo and iPS cells. PLoS ONE. 2012;7:e49079 pubmed publisher
Shifley E, Kenny A, Rankin S, Zorn A. Prolonged FGF signaling is necessary for lung and liver induction in Xenopus. BMC Dev Biol. 2012;12:27 pubmed publisher
Rankin S, Gallas A, Neto A, Gomez Skarmeta J, Zorn A. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Development. 2012;139:3010-20 pubmed publisher
Cho L, Wamaitha S, Tsai I, Artus J, Sherwood R, Pedersen R, et al. Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. Development. 2012;139:2866-77 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Gibson N, Tolbert L, Oland L. Activation of glial FGFRs is essential in glial migration, proliferation, and survival and in glia-neuron signaling during olfactory system development. PLoS ONE. 2012;7:e33828 pubmed publisher

product information

brand :

Tocris

master code :

3044

SKU :

3044/10

product name :

PD 173074

description :

FGFR1 and -3 inhibitor

target :

FGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

523.67

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Also promotes mESC self-renewal, facilitates the conversion of mouse epiblast stem cells to an earlier pluripotency state and inhibts differentiation of miPSCs to cardiomyocytes. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.

catalog number base :

3044

product keywords :

Selective FGFR1 FGFR3 inhibitors inhibits fibroblast growth factors PD173074 stem cells Pfizer FGFR Stem Cell Proliferation Neural Stem Cells 3044,

extended description :

FGFR1 and -3 inhibitor

chemical name text :

N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N -(1,1-dimethylethyl)urea

formula :

C 28 H 41 N 7 O 3

formula text :

C28H41N7O3

cas num :

219580-11-7

2020 USD :

220

2021 USD :

231 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage