product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PD 173074
catalog :
3044/10
quantity :
10 mg (also 50 mg)
price :
300 USD
more info or order :
Tocris Bioscience product webpage
citations: 22
Reference
Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, et al. The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches. Cell Rep. 2019;29:2028-2040.e8 pubmed publisher
Bise T, de Preux Charles A, Jazwinska A. Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart. NPJ Regen Med. 2019;4:2 pubmed publisher
Yuan X, Cao X, Yang S. IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development. Cell Death Dis. 2019;10:63 pubmed publisher
Adkar S, Wu C, Willard V, Dicks A, Ettyreddy A, Steward N, et al. Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing. Stem Cells. 2019;37:65-76 pubmed publisher
Takata N, Sakakura E, Eiraku M, Kasukawa T, Sasai Y. Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism. Nat Commun. 2017;8:1339 pubmed publisher
Nacu E, Gromberg E, Oliveira C, Drechsel D, Tanaka E. FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration. Nature. 2016;533:407-10 pubmed publisher
Lichtenberger B, Mastrogiannaki M, Watt F. Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages. Nat Commun. 2016;7:10537 pubmed publisher
Anreddy N, Patel A, Sodani K, Kathawala R, Chen E, Wurpel J, et al. PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR. Acta Pharm Sin B. 2014;4:202-7 pubmed publisher
MacKenzie B, Korfei M, Henneke I, Sibinska Z, Tian X, Hezel S, et al. Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis. Respir Res. 2015;16:83 pubmed publisher
Yang J, Kaur K, Ong L, Eisenberg C, Eisenberg L. Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors. Stem Cells Int. 2015;2015:270428 pubmed publisher
Knuchel S, Anderle P, Werfelli P, Diamantis E, Rüegg C. Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesion. Oncotarget. 2015;6:14300-17 pubmed
Benzina S, Pitaval A, Lemercier C, Lustremant C, Frouin V, Wu N, et al. A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. Cell Mol Life Sci. 2015;72:3559-73 pubmed publisher
Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, et al. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma. BMC Cancer. 2015;15:82 pubmed publisher
Witty A, Mihic A, Tam R, Fisher S, Mikryukov A, Shoichet M, et al. Generation of the epicardial lineage from human pluripotent stem cells. Nat Biotechnol. 2014;32:1026-35 pubmed publisher
Rankin S, Thi Tran H, Wlizla M, Mancini P, Shifley E, Bloor S, et al. A Molecular atlas of Xenopus respiratory system development. Dev Dyn. 2015;244:69-85 pubmed publisher
Wiener Z, Band A, Kallio P, Högström J, Hyvönen V, Kaijalainen S, et al. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β. Proc Natl Acad Sci U S A. 2014;111:E2229-36 pubmed publisher
Rodriguez A, Allegrucci C, Alberio R. Modulation of pluripotency in the porcine embryo and iPS cells. PLoS ONE. 2012;7:e49079 pubmed publisher
Shifley E, Kenny A, Rankin S, Zorn A. Prolonged FGF signaling is necessary for lung and liver induction in Xenopus. BMC Dev Biol. 2012;12:27 pubmed publisher
Rankin S, Gallas A, Neto A, Gomez Skarmeta J, Zorn A. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Development. 2012;139:3010-20 pubmed publisher
Cho L, Wamaitha S, Tsai I, Artus J, Sherwood R, Pedersen R, et al. Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. Development. 2012;139:2866-77 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Gibson N, Tolbert L, Oland L. Activation of glial FGFRs is essential in glial migration, proliferation, and survival and in glia-neuron signaling during olfactory system development. PLoS ONE. 2012;7:e33828 pubmed publisher
product information
brand :
Tocris
catalog number base :
3044
SKU :
3044/10
product name :
PD 173074
units size :
10 mg (also 50 mg)
description :
FGFR1 and -3 inhibitor
target :
FGF Receptor Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
523.67
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
review stars :
5
details of functionality :
PD 173074 is a selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Also promotes mESC self-renewal, facilitates the conversion of mouse epiblast stem cells to an earlier pluripotency state and inhibits differentiation of miPSCs to cardiomyocytes. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.
top caption :
FGFR1 and -3 inhibitor
extended description :
FGFR1 and -3 inhibitor
chemical name text :
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N -(1,1-dimethylethyl)urea
formula :
C28H41N7O3
formula text :
C28H41N7O3
cas num :
219580-11-7
USD :
300 USD
product details :
FGFR1 and -3 inhibitor
storage :
Store at +4°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK