product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SU 5416
catalog :
3037
quantity :
10 mg (also 50 mg)
price :
164 USD
more info or order :
citations: 12
Reference
Longchamp A, Mirabella T, Arduini A, MacArthur M, Das A, Treviño Villarreal J, et al. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 2018;173:117-129.e14 pubmed publisher
Meloche J, Lampron M, Nadeau V, Maltais M, Potus F, Lambert C, et al. Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2017;37:1513-1523 pubmed publisher
Neto Neves E, Brown M, Zaretskaia M, Rezania S, Goodwill A, McCarthy B, et al. Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition. Am J Pathol. 2017;187:700-712 pubmed publisher
Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
Happé C, de Raaf M, Rol N, Schalij I, Vonk Noordegraaf A, Westerhof N, et al. Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats. Am J Physiol Lung Cell Mol Physiol. 2016;310:L1088-97 pubmed publisher
Azzi S, Treps L, Leclair H, Ngo H, Harford Wright E, Gavard J. Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma. Front Pharmacol. 2015;6:281 pubmed publisher
Long L, Ormiston M, Yang X, Southwood M, Gräf S, Machado R, et al. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nat Med. 2015;21:777-85 pubmed publisher
Cavasin M, Demos Davies K, Schuetze K, Blakeslee W, Stratton M, Tuder R, et al. Reversal of severe angioproliferative pulmonary arterial hypertension and right ventricular hypertrophy by combined phosphodiesterase-5 and endothelin receptor inhibition. J Transl Med. 2014;12:314 pubmed publisher
DiStefano P, Kuebel J, Sarelius I, Glading A. KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling. J Biol Chem. 2014;289:33054-65 pubmed publisher
Chabon J, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, et al. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension. Pulm Circ. 2014;4:289-99 pubmed publisher
Hempel C, Hoyer N, Staalsø T, Kurtzhals J. Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum. Malar J. 2014;13:201 pubmed publisher
Novitskiy S, Csiki I, Huang Y, Johnson D, Harth E, Carbone D, et al. Anti-vascular endothelial growth factor treatment in combination with chemotherapy delays hematopoietic recovery due to decreased proliferation of bone marrow hematopoietic progenitor cells. J Thorac Oncol. 2010;5:1410-5 pubmed publisher
product information
brand :
Tocris
master code :
3037
SKU :
3037/10
product name :
SU 5416
description :
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
target :
VEGF Receptor Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
238.28
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types.
catalog number base :
3037
product keywords :
VEGFR inhibits inhibitors c-kit KIT Ret cMET FLT3 Hepatocyte Growth Factor Receptors HGFR RTK Receptor Tyrosine Kinases RTKs Vascular Endothelial KDR SU5416 Semaxinib VEGFR MET Receptors Other RTKs FLT3 3037, VEGFR, VEGF R
extended description :
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
chemical name text :
3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
formula :
C 15 H 14 N 2 O
formula text :
C15H14N2O
cas num :
204005-46-9
2020 USD :
157
2021 USD :
164 USD
alt names :
Semaxinib
storage :
Desiccate at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK