SU 5416 | Tocris Bioscience 3037/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SU 5416

catalog :

3037/10

quantity :

10 mg (also 50 mg)

price :

205 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Longchamp A, Mirabella T, Arduini A, MacArthur M, Das A, Treviño Villarreal J, et al. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 2018;173:117-129.e14 pubmed publisher
Meloche J, Lampron M, Nadeau V, Maltais M, Potus F, Lambert C, et al. Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2017;37:1513-1523 pubmed publisher
Neto Neves E, Brown M, Zaretskaia M, Rezania S, Goodwill A, McCarthy B, et al. Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition. Am J Pathol. 2017;187:700-712 pubmed publisher
Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
HappÃ© C, de Raaf M, Rol N, Schalij I, Vonk Noordegraaf A, Westerhof N, et al. Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats. Am J Physiol Lung Cell Mol Physiol. 2016;310:L1088-97 pubmed publisher
Azzi S, Treps L, Leclair H, Ngo H, Harford Wright E, Gavard J. Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma. Front Pharmacol. 2015;6:281 pubmed publisher
Long L, Ormiston M, Yang X, Southwood M, GrÃ¤f S, Machado R, et al. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nat Med. 2015;21:777-85 pubmed publisher
Cavasin M, Demos Davies K, Schuetze K, Blakeslee W, Stratton M, Tuder R, et al. Reversal of severe angioproliferative pulmonary arterial hypertension and right ventricular hypertrophy by combined phosphodiesterase-5 and endothelin receptor inhibition. J Transl Med. 2014;12:314 pubmed publisher
DiStefano P, Kuebel J, Sarelius I, Glading A. KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling. J Biol Chem. 2014;289:33054-65 pubmed publisher
Chabon J, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, et al. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension. Pulm Circ. 2014;4:289-99 pubmed publisher
Hempel C, Hoyer N, Staalsø T, Kurtzhals J. Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum. Malar J. 2014;13:201 pubmed publisher
Novitskiy S, Csiki I, Huang Y, Johnson D, Harth E, Carbone D, et al. Anti-vascular endothelial growth factor treatment in combination with chemotherapy delays hematopoietic recovery due to decreased proliferation of bone marrow hematopoietic progenitor cells. J Thorac Oncol. 2010;5:1410-5 pubmed publisher

image

image 1 :

Cat.No. 3037 - SU 5416 C15H14N2O CAS No. 204005-46-9

product information

brand :

Tocris

MasterCode :

3037

SKU :

3037/10

product name :

SU 5416

target :

VEGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

238.28

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SU 5416, an angiogenesis inhibitor, is a potent vascular endothelial growth factor receptor tyrosine kinase 1/2 inhibitor (IC50 = 40 nM). SU 5416 also potently inhibits c-Kit, FLT3 and RET tyrosine kinases (IC50 values are 30 nM, 160 nM and 170 nM, respectively). SU 5416 shows inhibition of tumour growth and vascularization and can be used to generate an animal model of pulmonary arterial hypertension.

extended description :

VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

chemical name text :

3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one

formula :

C 15 H 14 N 2 O

formula text :

C15H14N2O

cas num :

204005-46-9

USD :

205 USD

product details :

VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

alt names :

Semaxinib

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage