NSC 109555 ditosylate | Tocris Bioscience 3034 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NSC 109555 ditosylate

catalog :

3034

quantity :

10 mg (also 50 mg)

price :

189 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Shirazi Fard S, All Ericsson C, Hallböök F. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle. 2014;13:408-17 pubmed publisher
Duong H, Hong Y, Kim J, Lee H, Yi Y, Kim Y, et al. Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine. J Cell Mol Med. 2013;17:1261-70 pubmed publisher
Luo Y, Lou S, Deng X, Liu Z, Li Y, Kleiboeker S, et al. Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol. 2011;85:8046-55 pubmed publisher

product information

brand :

Tocris

master code :

3034

SKU :

3034/10

product name :

NSC 109555 ditosylate

description :

Selective Chk2 inhibitor

target :

Checkpoint Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

752.86

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 M) that displays no effect on a range of other kinases including Chk1 (IC50 10 M). Inhibits histone H1 phosphorylation (IC50 = 0.24 M) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo .

catalog number base :

3034

product keywords :

Selective Chk2 inhibitors inhibits Checkpoint Kinases Control NSC109555 ditosylate DDUG Checkpoint Kinases Checkpoint Control Kinases 3034,

extended description :

Selective Chk2 inhibitor

chemical name text :

2,2 -[Carbonylbis(imino-4,1-phenyleneethylidyne]bishydrazinecarboximidamide) bis(4-methylbenzenesulfonate)

formula :

C 19 H 24 N 10 O.2C 7 H 8 O 3 S

formula text :

C19H24N10O.2C7H8O3S

cas num :

66748-43-4

2020 USD :

185

2021 USD :

189 USD

alt names :

DDUG

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage