THIQ | Tocris Bioscience 3032 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

THIQ

catalog :

3032

quantity :

1 mg

price :

271 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Garfield A, Li C, Madara J, Shah B, Webber E, Steger J, et al. A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 2015;18:863-71 pubmed publisher
Huang H, Tao Y. A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants. Int J Biol Sci. 2014;10:817-24 pubmed publisher
Sohn J, Harris L, Berglund E, Liu T, Vong L, Lowell B, et al. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell. 2013;152:612-9 pubmed publisher

product information

brand :

Tocris

master code :

3032

SKU :

3032/1

product name :

THIQ

description :

Potent and selective MC4 receptor agonist

target :

Melanocortin Receptor Agonists

category :

Small Molecules

unit size :

1 mg

purity :

95%

observed molecular weight :

589.17

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 1.2, 761 and 2067 nM for human MC4, MC3 and MC1 receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration.

catalog number base :

3032

product keywords :

Potent selective MC4R receptors agonists Melanocortin Melanocortin Receptors 3032,

extended description :

Potent and selective MC4 receptor agonist

chemical name text :

N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-trazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide

formula :

C 33 H 41 ClN 6 O 2

formula text :

C33H41ClN6O2

cas num :

312637-48-2

2020 USD :

258

2021 USD :

271 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage