Edelfosine | Tocris Bioscience 3022/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Edelfosine

catalog :

3022/10

quantity :

10 mg

price :

129 USD

citations: 9

Reference
Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, et al. PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun. 2017;8:1457 pubmed publisher
Pitt J, Wilcox K, Tortelli V, Diniz L, Oliveira M, Dobbins C, et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound A? oligomers. Mol Biol Cell. 2017;28:2623-2636 pubmed publisher
Ailte I, Lingelem A, Kvalvaag A, Kavaliauskiene S, Brech A, Koster G, et al. Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis. Traffic. 2017;18:176-191 pubmed publisher
Liu Z, Chen J, Mirando A, Wang C, Zuscik M, O Keefe R, et al. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal. 2015;8:ra71 pubmed publisher
Ozkucur N, Song B, Bola S, Zhang L, Reid B, Fu G, et al. NHE3 phosphorylation via PKC? marks the polarity and orientation of directionally migrating cells. Cell Mol Life Sci. 2014;71:4653-4663 pubmed publisher
Zhao L, Levine E. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 2014;111:1008-15 pubmed publisher
Korb E, Wilkinson C, Delgado R, Lovero K, Finkbeiner S. Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci. 2013;16:874-83 pubmed publisher
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher
Melchior B, Frangos J. G?q/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Am J Physiol Cell Physiol. 2012;303:C467-73 pubmed publisher

product information

brand :

Tocris

MasterCode :

3022

SKU :

3022/10

product name :

Edelfosine

unit sizes :

10 mg

description :

Selective PI-PLC inhibitor, also PAF receptor agonist

target :

Phospholipase Inhibitors

category :

Small Molecules

observed molecular weight :

523.73

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Edelfosine is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50= 9.6 M in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.

extended description :

Selective PI-PLC inhibitor, also PAF receptor agonist

chemical name text :

(7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide

formula :

C 27 H 58 NO 6 P

formula text :

C27H58NO6P

cas num :

77286-66-9

USD :

129 USD

product details :

Selective PI-PLC inhibitor, also PAF receptor agonist

alt names :

ET-18-OCH3

storage :

Store at -20°C