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company name :
Tocris Bioscience
product type :
chemical
product name :
Iressa
catalog :
3000/10
quantity :
10 mg (also 50 mg)
price :
200 USD
more info or order :
citations: 28
Reference
Suina K, Tsuchihashi K, Yamasaki J, Kamenori S, Shintani S, Hirata Y, et al. Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate-sensitive glutamate receptor signaling. Cancer Sci. 2018;109:3874-3882 pubmed publisher
Stanley A, Ashrafi G, Seddon A, Modjtahedi H. Synergistic effects of various Her inhibitors in combination with IGF-1R, C-MET and Src targeting agents in breast cancer cell lines. Sci Rep. 2017;7:3964 pubmed publisher
Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, et al. CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors. Sci Rep. 2017;7:46662 pubmed publisher
Merrouche Y, Fabre J, Curé H, Garbar C, Fuselier C, Bastid J, et al. IL-17E synergizes with EGF and confers in vitro resistance to EGFR-targeted therapies in TNBC cells. Oncotarget. 2016;7:53350-53361 pubmed publisher
Zhu X, Jiang H, Li J, Xu J, Fei Z. Anticancer Effects of Paris Saponins by Apoptosis and PI3K/AKT Pathway in Gefitinib-Resistant Non-Small Cell Lung Cancer. Med Sci Monit. 2016;22:1435-41 pubmed
Staberg M, Michaelsen S, Olsen L, Nedergaard M, Villingshøj M, Stockhausen M, et al. Combined EGFR- and notch inhibition display additive inhibitory effect on glioblastoma cell viability and glioblastoma-induced endothelial cell sprouting in vitro. Cancer Cell Int. 2016;16:34 pubmed publisher
Kurimoto R, Iwasawa S, Ebata T, Ishiwata T, Sekine I, Tada Y, et al. Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation. Int J Oncol. 2016;48:1825-36 pubmed publisher
Oda M, Iwaya K, Kikuchi R, Kobayashi T, Yoneda T, Nishikawa K, et al. Stathmin is involved in the cooperative effect of Zoledronic acid and gefitinib on bone homing breast cancer cells in vitro. J Bone Oncol. 2012;1:40-6 pubmed publisher
Li L, Huang W, Li K, Zhang K, Lin C, Han R, et al. Metformin attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway. Oncotarget. 2015;6:43605-19 pubmed publisher
Khelwatty S, Essapen S, Seddon A, Fan Z, Modjtahedi H. Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers. Br J Cancer. 2015;113:1010-9 pubmed publisher
Lindholm P, Sivapurapu N, Jovanovic B, Kajdacsy Balla A. Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-κB Activity. J Clin Cell Immunol. 2015;6: pubmed
Curran S, Vantangoli M, Boekelheide K, Morgan J. Architecture of Chimeric Spheroids Controls Drug Transport. Cancer Microenviron. 2015;8:101-9 pubmed publisher
Kleczko E, Kim J, Keysar S, Heasley L, Eagles J, Simon M, et al. An Inducible TGF-?2-TGF?R Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases. PLoS ONE. 2015;10:e0123600 pubmed publisher
Bill A, Gutierrez A, Kulkarni S, Kemp C, Bonenfant D, Voshol H, et al. ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. Oncotarget. 2015;6:9173-88 pubmed
Moody T, Nuche Berenguer B, Moreno P, Jensen R. CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells. J Mol Neurosci. 2015;56:663-72 pubmed publisher
Zhou Y, Zhang Y, Zou H, Cai N, Chen X, Xu L, et al. The multi-targeted tyrosine kinase inhibitor vandetanib plays a bifunctional role in non-small cell lung cancer cells. Sci Rep. 2015;5:8629 pubmed publisher
Wang X, Song H, Yu Q, Liu Q, Wang L, Liu Z, et al. Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefitinib. Oncol Rep. 2015;33:526-32 pubmed publisher
Qawasmi I, Shmuel M, Eyal S. Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging. Front Pharmacol. 2014;5:257 pubmed publisher
Sakurai M, Ozaki Y, Okuzaki D, Naito Y, Sasakura T, Okamoto A, et al. Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630. PLoS ONE. 2014;9:e100124 pubmed publisher
Li L, Han R, Xiao H, Lin C, Wang Y, Liu H, et al. Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal. Clin Cancer Res. 2014;20:2714-26 pubmed publisher
Moody T, Chan D, Mantey S, Moreno P, Jensen R. SR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner. Life Sci. 2014;100:25-34 pubmed publisher
Joannes A, Grelet S, Duca L, Gilles C, Kileztky C, Dalstein V, et al. Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells. Mol Cancer Res. 2014;12:775-83 pubmed publisher
Smith A, Bowers S, Stratman A, Davis G. Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions. PLoS ONE. 2013;8:e85147 pubmed publisher
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McMellen M, Wakeman D, Erwin C, Guo J, Warner B. Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection. Surgery. 2010;148:364-70 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3000
SKU :
3000/10
product name :
Iressa
description :
Orally active, selective EGFR inhibitor
target :
EGF Receptor Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at RT
observed molecular weight :
446.9
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Iressa is an orally active, selective inhibitor of EGFR tyrosine kinase (IC50 = 23 - 79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts. Also inhibits growth of brain metastases in mouse model of non-small cell lung cancer. . View information regarding the usage of Iressa for non-clinical studies .
product keywords :
Orally active selective EGFR inhibitors inhibits Epidermal Growth Factors Receptors ErbB Her Receptor Tyrosine Kinases RTKs AstraZeneca ZD1839 chemotherapeutics Gefitinib ZD 1839 EGFR Organoids 3000,
extended description :
Orally active, selective EGFR inhibitor
chemical name text :
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
formula :
C22H24ClFN4O3
formula text :
C22H24ClFN4O3
cas num :
184475-35-2
USD :
198
USD 2025 :
200 USD
product details :
Orally active, selective EGFR inhibitor
alt names :
Gefitinib,ZD 1839
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK