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company name :
Tocris Bioscience
product type :
chemical
product name :
RS 127445 hydrochloride
catalog :
2993/10
quantity :
10 mg (also 50 mg)
price :
256 USD
more info or order :
citations: 8
Reference
Löfdahl A, Rydell Törmänen K, Larsson Callerfelt A, Wenglén C, Westergren Thorsson G. Pulmonary fibrosis in vivo displays increased p21 expression reduced by 5-HT2B receptor antagonists in vitro - a potential pathway affecting proliferation. Sci Rep. 2018;8:1927 pubmed publisher
Moutkine I, Quentin E, Guiard B, Maroteaux L, Doly S. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers. J Biol Chem. 2017;292:6352-6368 pubmed publisher
Palmqvist N, Siller M, Klint C, Sjödin A. A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030. J Inflamm (Lond). 2016;13:20 pubmed publisher
Tanaka T, Doe J, Horstmann S, Ahmad S, Ahmad A, Min S, et al. Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells. J Biol Chem. 2014;289:10466-75 pubmed publisher
Chabbi Achengli Y, Launay J, Maroteaux L, de Vernejoul M, Collet C. Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ß/? in osteoblasts. PLoS ONE. 2013;8:e75783 pubmed publisher
Söhle J, Machuy N, Smailbegovic E, Holtzmann U, Grönniger E, Wenck H, et al. Identification of new genes involved in human adipogenesis and fat storage. PLoS ONE. 2012;7:e31193 pubmed publisher
Murray K, Stephens M, Rank M, D Amico J, Gorassini M, Bennett D. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011;106:925-43 pubmed publisher
Banas S, Doly S, Boutourlinsky K, Diaz S, Belmer A, Callebert J, et al. Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects. Neuropsychopharmacology. 2011;36:423-33 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2993
SKU :
2993/10
product name :
RS 127445 hydrochloride
description :
High affinity and selective 5-HT2B antagonist
target :
5-HT2B Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Desiccate at +4°C
observed molecular weight :
317.79
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
RS 127445 hydrochloride is a high affinity 5-HT2B receptor antagonist (pKi = 9.5). Displays 1000-fold selectivity for 5-HT2B with good bioavailability.
product keywords :
Selective high affinity 5-HT2B antagonists Serotonin Receptors RS127445 hydrochloride MT500 MT 500 5-HT2B Receptors 2993,
extended description :
High affinity and selective 5-HT2B antagonist
chemical name text :
4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine hydrochloride
formula :
C17H16FN3.HCl
formula text :
C17H16FN3.HCl
cas num :
199864-86-3
USD :
253
USD 2025 :
256 USD
product details :
High affinity and selective 5-HT2B antagonist
alt names :
MT 500
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK