PKC 412 | Tocris Bioscience 2992 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PKC 412

catalog :

2992

quantity :

1 mg

price :

187 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Moloney J, Stanicka J, Cotter T. Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia. Leuk Res. 2017;52:34-42 pubmed publisher
Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed publisher
Kuan C, Yee Y, See Too W, Few L. Ets and GATA transcription factors play a critical role in PMA-mediated repression of the ckÎ² promoter via the protein kinase C signaling pathway. PLoS ONE. 2014;9:e113485 pubmed publisher
Woolley J, Naughton R, Stanicka J, Gough D, Bhatt L, Dickinson B, et al. H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PLoS ONE. 2012;7:e34050 pubmed publisher
Wasag B, Lierman E, Meeus P, Cools J, Vandenberghe P. The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11). Haematologica. 2011;96:922-6 pubmed publisher

product information

brand :

Tocris

master code :

2992

SKU :

2992/1

product name :

PKC 412

description :

Protein kinase C inhibitor

target :

Protein Kinase C Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

570.64

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms ( , , ), PDFR , VEGFR2, Syk, PKC , Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1, EGFR and MARK (microtubule affinity regulating kinase). Displays potent antitumor activity. Identified as targeting human host cell proteins that interact with SARS-CoV-2.

catalog number base :

2992

product keywords :

Broad spectrum protein kinases inhibitors inhibits conventional PKC PKC412 CGP41251 COVID-19 SARS-CoV-2 severe acute respiratory syndrome CGP 41251 Protein Kinase C Broad Spectrum Protein Kinase Inhibitors COVID-19 Coronavirus 2992,

extended description :

Protein kinase C inhibitor

chemical name text :

[9S-(9 ,10 ,11 ,13 )]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3 ,2 ,1 -lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide

formula :

C 35 H 30 N 4 O 4

formula text :

C35H30N4O4

cas num :

120685-11-2

2020 USD :

181

2021 USD :

187 USD

alt names :

CGP 41251

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage